Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T82105 Target Info
Target Name Biliary glycoprotein 1 (CEACAM1)
Synonyms Biliary glycoprotein 1; BGP-1; DE AltName: CD_antigen=CD66a
Target Type Clinical trial Target
Gene Name CEACAM1
UniProt ID
CEAM1_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: B-Octylglucoside Ligand Info
Structure Description Crystal structure of E99A mutant of human CEACAM1 PDB:6XNO
Method X-ray diffraction Resolution 1.90 Å Mutation Yes [1]
PDB Sequence
QLTTESMPFN
10
VAEGKEVLLL
20
VHNLPQQLFG
30
YSWYKGERVD
40
GNRQIVGYAI
50

GTQQATPGPA
60
NSGRETIYPN
70
ASLLIQNVTQ
80
NDTGFYTLQV
90
IKSDLVNEAA
100

TGQFHVY
Residue
Distance (Å)
LEU18
4.073
LEU19
4.597
LEU20
3.116
VAL21
2.754
HIS22
2.980
Residue
Distance (Å)
TYR68
3.620
ASN70
3.132
SER72
2.346
LEU74
4.310
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References  Top
REF 1 Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium. Commun Biol. 2021 Mar 19;4(1):360.

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