Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T81780 | Target Info | |||
| Target Name | Ubiquitin-activating enzyme E1 (UBAE1) | ||||
| Synonyms | Ubiquitin-like modifier-activating enzyme 1; UBE1; Protein A1S9; A1S9T | ||||
| Target Type | Patented-recorded Target | ||||
| Gene Name | UBA1 | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Pyrophosphate 2- | Ligand Info | |||||
| Structure Description | Crystal structure of human ubiquitin activating enzyme E1 (Uba1) in complex with ubiquitin | PDB:6DC6 | ||||
| Method | X-ray diffraction | Resolution | 3.14 Å | Mutation | Yes | [1] |
| PDB Sequence |
DIDEGLYSRQ
58 LYVLGHEAMK68 RLQTSSVLVS78 GLRGLGVEIA88 KNIILGGVKA98 VTLHDQGTAQ 108 WADLSSQFYL118 REEDIGKNRA128 EVSQPRLAEL138 NSYVPVTAYT148 GPLVEDFLSG 158 FQVVVLTNTP168 LEDQLRVGEF178 CHNRGIKLVV188 ADTRGLFGQL198 FCDFGEEMIL 208 TDSNGEQPLS218 AMVSMVTKDN228 PGVVTCLDEA238 RHGFESGDFV248 SFSEVQGMVE 258 LNGNQPMEIK268 VLGPYTFSIC278 DTSNFSDYIR288 GGIVSQVKVP298 KKISFKSLVA 308 SLAEPDFVVT318 DFAKFSRPAQ328 LHIGFQALHQ338 FCAQHGRPPR348 PRNEEDAAEL 358 VALAQAVNAR368 ALPAVQQNNL378 DEDLIRKLAY388 VAAGDLAPIN398 AFIGGLAAQE 408 VMKACSGKFM418 PIMQWLYFDA428 LECLPEDKEV438 LTEDKCLQRQ448 NRYDGQVAVF 458 GSDLQEKLGK468 QKYFLVGAGA478 IGCELLKNFA488 MIGLGCGEGG498 EIIVTDMDTI 508 EKSNLNRQFL518 FRPWDVTKLK528 SDTAAAAVRQ538 MNPHIRVTSH548 QNRVGPDTER 558 IYDDDFFQNL568 DGVANALDNV578 DARMYMDRRC588 VYYRKPLLES598 GTLGTKGNVQ 608 VVIPFLTESY618 SSSQDPPEKS628 IPIATLKNFP638 NAIEHTLQWA648 RDEFEGLFKQ 658 PAENVNQYLT668 DPKFVERTLR678 LAGTQPLEVL688 EAVQRSLVLQ698 RPQTWADCVT 708 WACHHWHTQY718 SNNIRQLLHN728 FPPDQLTSSG738 APFWSGPKRC748 PHPLTFDVNN 758 PLHLDYVMAA768 ANLFAQTYGL778 TGSQDRAAVA788 TFLQSVQVPE798 FTPKSVDDSR 825 LEELKATLPS835 PDKLPGFKMY845 PIDFEKDDDS855 NFHMDFIVAA865 SNLRAENYDI 875 PSADRHKSKL885 IAGKIIPAIA895 TTTAAVVGLV905 CLELYKVVQG915 HRQLDSYKNG 925 FLNLALPFFG935 FSEPLAAPRH945 QYYNQEWTLW955 DRFEVQGLQP965 NGEEMTLKQF 975 LDYFKTEHKL985 EITMLSQGVS995 MLYSFFMPAA1005 KLKERLDQPM1015 TEIVSRVSKR 1025 KLGRHVRALV1035 LELCCNDESG1045 EDVEVPYVRY1055 TI
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Crystal structure of a human ubiquitin E1-ubiquitin complex reveals conserved functional elements essential for activity. J Biol Chem. 2018 Nov 23;293(47):18337-18352. | ||||
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