Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T81569 Target Info
Target Name Zinc finger protein Helios (IKZF2)
Synonyms Ikaros family zinc finger protein 2
Target Type Clinical trial Target
Gene Name IKZF2
UniProt ID
IKZF2_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: 3-[3-[[1-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-2,5-bis(oxidanylidene)pyrrol-3-yl]amino]phenyl]-~{N}-(3-chloranyl-4-methyl-phenyl)propanamide Ligand Info
Structure Description Crystal structure of DDB1-CRBN-ALV1 complex bound to Helios (IKZF2 ZF2) PDB:7LPS
Method X-ray diffraction Resolution 3.78 Å Mutation No [1]
PDB Sequence
GERPFHCNQC
145
GASFTQKGNL
155
LRHIKLHSG
Residue
Distance (Å)
HIS141
3.467
CYS142
3.239
ASN143
4.022
Residue
Distance (Å)
GLN144
3.499
CYS145
2.972
GLY146
3.455
References  Top
REF 1 Acute pharmacological degradation of Helios destabilizes regulatory T cells. Nat Chem Biol. 2021 Jun;17(6):711-717.

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