Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T81547 Target Info
Target Name Solute carrier family 13 member 5 (SLC13A5)
Synonyms Sodium-coupled citrate transporter; SLC13A5; NaCT; Na(+)-coupled citrate transporter; Human sodium-coupled citrate transporter
Target Type Literature-reported Target
Gene Name SLC13A5
UniProt ID
S13A5_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: (2R)-2-[2-(4-tert-butylphenyl)ethyl]-2-hydroxybutanedioic acid Ligand Info
Structure Description Structure of the NaCT-PF2 complex PDB:7JSJ
Method Electron microscopy Resolution 3.12 Å Mutation No [1]
PDB Sequence
SFVILFVTPL
22
LLLPLVILMP
32
AKFVRCAYVI
42
ILMAIYWCTE
52
VIPLAVTSLM
62

PVLLFPLFQI
72
LDSRQVCVQY
82
MKDTNMLFLG
92
GLIVAVAVER
102
WNLHKRIALR
112

TLLWVGAKPA
122
RLMLGFMGVT
132
ALLSMWISNT
142
ATTAMMVPIV
152
EAILQQRKRL
204

CKAMTLCICY
214
AASIGGTATL
224
TGTGPNVVLL
234
GQMNELFPDS
244
KDLVNFASWF
254

AFAFPNMLVM
264
LLFAWLWLQF
274
VYMRSKKNEK
296
AALKVLQEEY
306
RKLGPLSFAE
316

INVLICFFLL
326
VILWFSRDPE
350
TKYVSDATVA
360
IFVATLLFIV
370
PSQKPKFYPP
394

PLLDWKVTQE
404
KVPWGIVLLL
414
GGGFALAKGS
424
EASGLSVWMG
434
KQMEPLHAVP
444

PAAITLILSL
454
LVAVFTECTS
464
NVATTTLFLP
474
IFASMSRSIG
484
LNPLYIMLPC
494

TLSASFAFML
504
PVATPPNAIV
514
FTYGHLKVAD
524
MVKTGVIMNI
534
IGVFCVFLAV
544

NTWGRAIFDL
554
DHFPDWAN
Residue
Distance (Å)
LEU56
2.955
ALA57
3.956
PHE90
3.925
SER140
3.068
ASN141
2.530
THR142
2.290
GLY226
3.723
THR227
1.640
GLY228
2.418
PRO229
3.344
PRO407
2.696
Residue
Distance (Å)
TRP408
4.103
GLY409
2.223
ILE410
2.176
VAL411
4.842
LEU413
3.124
SER464
3.417
ASN465
2.663
VAL466
2.745
THR508
3.270
PRO509
2.868
PRO510
4.016
References  Top
REF 1 Structure and inhibition mechanism of the human citrate transporter NaCT. Nature. 2021 Mar;591(7848):157-161.

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