Binding Site Information of Target
Target General Information | Top | ||||
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Target ID | T81452 | Target Info | |||
Target Name | Monoacylglycerol lipase ABHD6 (ABHD6) | ||||
Synonyms | Abhydrolase domain-containing protein 6; 2-arachidonoylglycerol hydrolase | ||||
Target Type | Patented-recorded Target | ||||
Gene Name | ABHD6 | ||||
Biochemical Class | Carboxylic ester hydrolase | ||||
UniProt ID |
Drug Binding Sites of Target | Top | |||||
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Ligand Name: B-Octylglucoside | Ligand Info | |||||
Structure Description | Crystal structure of human Monoacylglycerol Lipase ABHD6 in complex with oleic acid and octyl glucoside | PDB:7OTS | ||||
Method | X-ray diffraction | Resolution | 1.79 Å | Mutation | Yes | [1] |
PDB Sequence |
TLGMQVRYVH
54 HEDYQFCYSF64 RGRPGHKPSI74 LMLHGFSAHK84 DMWLSVVKFL94 PKNLHLVCVD 104 MPGHEGTTRS114 SLDDLSIDGQ124 VKRIHQFVEC134 LKLNKKPFHL144 VGTAMGGQVA 154 GVYAAYYPSD164 VSSLCLVCPA174 GLQYSTDNQF184 VQRLKELQGS194 AAVEKIPLIP 204 STPEEMSEML214 QLCSYVRFKV224 PQQILQGLVD234 VRIPHNNFYR244 KLFLEIVSEK 254 SRYSLHQNMD264 KIKVPTQIIW274 GKQDQVLDVS284 GADMLAKSIA294 NCQVELLENC 304 GHSVVMERPR314 KTAKLIIDFL324 ASVHNTDNNK334 KL
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Ligand Name: Oleic acid | Ligand Info | |||||
Structure Description | Crystal structure of human Monoacylglycerol Lipase ABHD6 in complex with oleic acid and octyl glucoside | PDB:7OTS | ||||
Method | X-ray diffraction | Resolution | 1.79 Å | Mutation | Yes | [1] |
PDB Sequence |
TLGMQVRYVH
54 HEDYQFCYSF64 RGRPGHKPSI74 LMLHGFSAHK84 DMWLSVVKFL94 PKNLHLVCVD 104 MPGHEGTTRS114 SLDDLSIDGQ124 VKRIHQFVEC134 LKLNKKPFHL144 VGTAMGGQVA 154 GVYAAYYPSD164 VSSLCLVCPA174 GLQYSTDNQF184 VQRLKELQGS194 AAVEKIPLIP 204 STPEEMSEML214 QLCSYVRFKV224 PQQILQGLVD234 VRIPHNNFYR244 KLFLEIVSEK 254 SRYSLHQNMD264 KIKVPTQIIW274 GKQDQVLDVS284 GADMLAKSIA294 NCQVELLENC 304 GHSVVMERPR314 KTAKLIIDFL324 ASVHNTDNNK334 KL
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GLY79
3.749
PHE80
2.815
THR147
4.905
ALA148
3.174
MET149
3.209
ALA174
4.297
PHE184
4.105
VAL185
3.818
LEU188
3.546
LYS189
3.826
GLN192
3.578
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References | Top | ||||
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REF 1 | Crystal structure of human Monoacylglycerol Lipase ABHD6 in complex with oleic acid and octyl glucoside |
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