Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T81386 | Target Info | |||
| Target Name | Positive transcription elongation factor b (P-TEFb) | ||||
| Synonyms | P-TEFb | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | CDK9-CCNT1 | ||||
| Biochemical Class | S-phase kinase-associated protein | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Phosphonothreonine | Ligand Info | |||||
| Structure Description | crystal structure of P-TEFb complex with AFF4 and Tat | PDB:4OGR | ||||
| Method | X-ray diffraction | Resolution | 3.00 Å | Mutation | No | [1] |
| PDB Sequence |
NNNKRWYFTR
16 EQLENSPSRR26 FGVDPDKELS36 YRQQAANLLQ46 DMGQRLNVSQ56 LTINTAIVYM 66 HRFYMIQSFT76 QFPGNSVAPA86 ALFLAAKVEE96 QPKKLEHVIK106 VAHTCLHPQE 116 SLPDTRSEAY126 LQQVQDLVIL136 ESIILQTLGF146 ELTIDHPHTH156 VVKCTQLVRA 166 SKDLAQTSYF176 MATNSLHLTT186 FSLQYTPPVV196 ACVCIHLACK206 WSNWEIPVST 216 DGKHWWEYVD226 ATVTLELLDE236 LTHEFLQILE246 KTPNRLKRIW256 NWRAC |
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | AFF4 binding to Tat-P-TEFb indirectly stimulates TAR recognition of super elongation complexes at the HIV promoter. Elife. 2014 Apr 24;3:e02375. | ||||
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