Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T81281 | Target Info | |||
| Target Name | Desmoglein-3 (DSG3) | ||||
| Synonyms | PVA; DSG3; Cadherin family member 6; 130 kDa pemphigus vulgaris antigen | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | DSG3 | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Alpha-D-Mannose | Ligand Info | |||||
| Structure Description | Crystal structure of human Desmoglein-3 ectodomain | PDB:5EQX | ||||
| Method | X-ray diffraction | Resolution | 3.05 Å | Mutation | No | [1] |
| PDB Sequence |
EWVKFAKPCR
10 EGEDNSKRNP20 IAKITSDYQA30 TQKITYRISG40 VGIDQPPFGI50 FVVDKNTGDI 60 NITAIVDREE70 TPSFLITCRA80 LNAQGLDVEK90 PLILTVKILD100 INDNPPVFSQ 110 QIFMGEIEEN120 SASNSLVMIL130 NATDADEPNH140 LNSKIAFKIV150 SQEPAGTPMF 160 LLSRNTGEVR170 TLTNSLDREQ180 ASSYRLVVSG190 ADKDGEGLST200 QCECNIKVKD 210 VNDNFPMFRD220 SQYSARIEEN230 ILSSELLRFQ240 VTDLDEEYTD250 NWLAVYFFTS 260 GNEGNWFEIQ270 TDPRTNEGIL280 KVVKALDYEQ290 LQSVKLSIAV300 KNKAEFHQSV 310 ISRYRVQSTP320 VTIQVINVRE330 GIAFRPASKT340 FTVQKGISSK350 KLVDYILGTY 360 QAIDEDTNKA370 ASNVKYVMGR380 NDGGYLMIDS390 KTAEIKFVKN400 MNRDSTFIVN 410 KTITAEVLAI420 DEYTGKTSTG430 TVYVRVPDF
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural basis of adhesive binding by desmocollins and desmogleins. Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7160-5. | ||||
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