Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T79400 | Target Info | |||
| Target Name | Kallikrein-4 (KLK4) | ||||
| Synonyms | Serine protease 17; Prostase; PSTS; PRSS17; Kallikreinlike protein 1; Kallikrein4; Kallikrein-like protein 1; KLKL1; KLK-L1; Enamel matrix serine proteinase 1; EMSP1 | ||||
| Target Type | Patented-recorded Target | ||||
| Gene Name | KLK4 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Urea | Ligand Info | |||||
| Structure Description | Crystal structure of BbKI complexed with Human Kallikrein 4 | PDB:7JOW | ||||
| Method | X-ray diffraction | Resolution | 1.91 Å | Mutation | No | [1] |
| PDB Sequence |
IINGEDCSPH
25 SQPWQAALVM35 ENELFCSGVL46 VHPQWVLSAA56 HCFQNSYTIG66 LGLHSLEADQ 76 EPGSQMVEAS86 LSVRHPEYNR96 PLLANDLMLI106 KLDESVSESD116 TIRSISIASQ 127 CPTAGNSCLV138 SGWGLLANGR150 MPTVLQCVNV160 SVVSEEVCSK170 LYDPLYHPSM 180 FCAGGGQDQK188 DSCNGDSGGP198 LICNGYLQGL212 VSFGKAPCGQ221 VGVPGVYTNL 231 CKFTEWIEKT241 VQA
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| Ligand Name: P-Amino benzamidine | Ligand Info | |||||
| Structure Description | Human Kallikrein 4 complex with nickel and p-aminobenzamidine | PDB:2BDG | ||||
| Method | X-ray diffraction | Resolution | 1.95 Å | Mutation | No | [2] |
| PDB Sequence |
IINGEDCSPH
25 SQPWQAALVM35 ENELFCSGVL46 VHPQWVLSAA56 HCFQNSYTIG66 LGLHSLEADQ 76 EPGSQMVEAS86 LSVRHPEYNR96 PLLANDLMLI106 KLDESVSESD116 TIRSISIASQ 127 CPTAGNSCLV138 SGWGLLANGR150 MPTVLQCVNV160 SVVSEEVCSK170 LYDPLYHPSM 180 FCAGGGQDQK188 DSCNGDSGGP198 LICNGYLQGL212 VSFGKAPCGQ221 VGVPGVYTNL 231 CKFTEWIEKT241 VQA
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural studies of complexes of kallikrein 4 with wild-type and mutated forms of the Kunitz-type inhibitor BbKI. doi:10.1107/S2059798321006483. | ||||
| REF 2 | Crystal structures of human tissue kallikrein 4: activity modulation by a specific zinc binding site. J Mol Biol. 2006 Oct 6;362(5):1094-107. | ||||
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