Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T78350 Target Info
Target Name Melanoma derived growth regulator (MIA)
Synonyms Melanoma-derived growth regulatory protein; Melanoma inhibitory activity protein
Target Type Literature-reported Target
Gene Name MIA
UniProt ID
MIA_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: 2-Aminopyrimidine Ligand Info
Structure Description Structure of human Melanoma Inhibitory Activity (MIA) Protein in complex with Pyrimidin-2-amine PDB:5IXB
Method X-ray diffraction Resolution 1.39 Å Mutation No [1]
PDB Sequence
MPKLADRKLC
12
ADQECSHPIS
22
MAVALQDYMA
32
PDCRFLTIHR
42
GQVVYVFSKL
52

KGRGRLFWGG
62
SVQGDYYGDL
72
AARLGYFPSS
82
IVREDQTLKP
92
GKVDVKTDKW
102

DFYCQ
Residue
Distance (Å)
ARG36
4.215
SER50
3.441
GLY61
2.701
GLY62
4.069
LEU76
2.650
GLY77
2.455
TYR78
3.009
Residue
Distance (Å)
TRP102
2.862
ASP103
3.056
PHE104
3.472
TYR105
2.473
CYS106
4.099
GLN107
2.458
References  Top
REF 1 Small Molecules Antagonise the MIA-Fibronectin Interaction in Malignant Melanoma. Sci Rep. 2016 May 6;6:25119.

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