Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T77181 Target Info
Target Name Ubiquitin thioesterase L3 (UCHL3)
Synonyms Ubiquitin carboxyl-terminal hydrolase isozyme L3; UCH-L3
Target Type Literature-reported Target
Gene Name UCHL3
Biochemical Class Peptidase
UniProt ID
UCHL3_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Methyl 4-aminobutanoate Ligand Info
Structure Description Crystal structure of UCHL3-UbVME complex PDB:1XD3
Method X-ray diffraction Resolution 1.45 Å Mutation No [1]
PDB Sequence
EGQRWLPLEA
11
NPEVTNQFLK
21
QLGLHPNWQF
31
VDVYGMDPEL
41
LSMVPRPVCA
51

VLLLFPITEK
61
YEVFRTEEEE
71
KIKSQGQDVT
81
SSVYFMKQTI
91
SNACGTIGLI
101

HAIANNKDKM
111
HFESGSTLKK
121
FLEESVSMSP
131
EERARYLENY
141
DAIRVTHETS
151

AHEGQTEAPS
161
IDEKVDLHFI
171
ALVHVDGHLY
181
ELDGRKPFPI
191
NHGETSDETL
201

LEDAIEVCKK
211
FMERDPDELR
221
FNAIALSAA
Residue
Distance (Å)
PRO8
3.921
ILE58
3.665
GLN89
3.483
ASN93
3.349
ALA94
4.522
CYS95
1.818
Residue
Distance (Å)
GLY96
4.774
VAL166
3.584
LEU168
3.027
HIS169
3.134
PHE170
4.727
ARG186
3.784
References  Top
REF 1 Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate. J Biol Chem. 2005 Jan 14;280(2):1512-20.

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