Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T77174 | Target Info | |||
| Target Name | mRNA cap guanine-N7 methyltransferase (RNMT) | ||||
| Synonyms | hcm1p; hMet; hCMT1; RG7MT1; KIAA0398 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | RNMT | ||||
| Biochemical Class | Methyltransferase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Sinefungin | Ligand Info | |||||
| Structure Description | Crystal structure of mRNA cap guanine-N7 methyltransferase (RNMT) in complex with sinefungin | PDB:3EPP | ||||
| Method | X-ray diffraction | Resolution | 2.41 Å | Mutation | No | [1] |
| PDB Sequence |
IFYLRNFNNW
15 MKSVLIGEFL25 EKVRQKKDIT37 VLDLGCGKGG47 DLLKWKKGRI57 NKLVCTDIAD 67 VSVKQCQQRY77 EDMKNRSEYI89 FSAEFITADS99 SKELLIDKFR109 DPQMCFDICS 119 CQFVCHYSFE129 SYEQADMMLR139 NACERLSPGG149 YFIGTTPNSF159 ELIRRLEASE 169 TESFGNEIYT179 VKFQKKGDYP189 LFGCKYDFND204 VPEFLVYFPL214 LNEMAKKYNM 224 KLVYKKTFLE234 FYEEKIKNNE244 NKMLLKRMQL288 PLGTLSKSEW298 EATSIYLVFA 308 FEKQQ
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Crystal structure of mRNA cap guanine-N7 methyltransferase (RNMT) in complex with sinefungin. | ||||
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