Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T76888 | Target Info | |||
| Target Name | Peroxiredoxin-4 (PRDX4) | ||||
| Synonyms | Thioredoxindependent peroxide reductase A0372; Thioredoxin peroxidase AO372; PrxIV; Peroxiredoxin4; Peroxiredoxin IV; PRDX4; Antioxidant enzyme AOE372; AOE372 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | PRDX4 | ||||
| Biochemical Class | Peroxidases | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 2-Mercaptoethanesulfonic acid | Ligand Info | |||||
| Structure Description | Crystal structure of human peroxiredoxin 4(THIOREDOXIN PEROXIDASE) with MESNA | PDB:4RQX | ||||
| Method | X-ray diffraction | Resolution | 2.26 Å | Mutation | No | [1] |
| PDB Sequence |
GTAKISKPAP
86 YWEGTAVIDG96 EFKELKLTDY106 RGKYLVFFFY116 PLDFTFVCPT126 EIIAFGDRLE 136 EFRSINTEVV146 ACSVDSQFTH156 LAWINTPRRQ166 GGLGPIRIPL176 LSDLTHQISK 186 DYGVYLEDSG196 HTLRGLFIID206 DKGILRQITL216 NDLPVGRSVD226 ETLRLVQAFQ 236 YTDKHG
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Cysteine specific targeting of the functionally distinct peroxiredoxin and glutaredoxin proteins by the investigational disulfide BNP7787. Molecules. 2015 Mar 18;20(3):4928-50. | ||||
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