Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T76497 | Target Info | |||
| Target Name | Phosphogluconate dehydrogenase (PGD) | ||||
| Synonyms | PGDH; 6PGDH; 6-phosphogluconate dehydrogenase, decarboxylating; 6-phosphogluconate dehydrogenase | ||||
| Target Type | Successful Target | ||||
| Gene Name | PGD | ||||
| Biochemical Class | CH-OH donor oxidoreductase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 3-Phosphoglyceric Acid | Ligand Info | |||||
| Structure Description | Crystal structure of 6-phosphogluconate dehydrogenase complexed with 3-phosphoglyceric acid | PDB:4GWK | ||||
| Method | X-ray diffraction | Resolution | 1.53 Å | Mutation | No | [1] |
| PDB Sequence |
AQADIALIGL
11 AVMGQNLILN21 MNDHGFVVCA31 FNRTVSKVDD41 FLANEAKGTK51 VVGAQSLKEM 61 VSKLKKPRRI71 ILLVKAGQAV81 DDFIEKLVPL91 LDTGDIIIDG101 GNSEYRDTTR 111 RCRDLKAKGI121 LFVGSGVSGG131 EEGARYGPSL141 MPGGNKEAWP151 HIKTIFQGIA 161 AKVGTGEPCC171 DWVGDEGAGH181 FVKMVHNGIE191 YGDMQLICEA201 YHLMKDVLGM 211 AQDEMAQAFE221 DWNKTELDSF231 LIEITANILK241 FQDTDGKHLL251 PKIRDSAGQK 261 GTGKWTAISA271 LEYGVPVTLI281 GEAVFARCLS291 SLKDERIQAS301 KKLKGPFQFD 313 GDKKSFLEDI323 RKALYASKII333 SYAQGFMLLR343 QAATEFGWTL353 NYGGIALMWR 363 GGCIIRSVFL373 GKIKDAFDRN383 PELQNLLLDD393 FFKSAVENCQ403 DSWRRAVSTG 413 VQAGIPMPCF423 TTALSFYDGY433 RHEMLPASLI443 QAQRDYFGAH453 TYELLAKPGQ 463 FIHTNWT
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| Ligand Name: NADP+ | Ligand Info | |||||
| Structure Description | Structure of human Phosphogluconate Dehydrogenase in complex with NADPH at 2.53A | PDB:2JKV | ||||
| Method | X-ray diffraction | Resolution | 2.53 Å | Mutation | No | [2] |
| PDB Sequence |
AQADIALIGL
11 AVMGQNLILN21 MNDHGFVVCA31 FNRTVSKVDD41 FLANEAKGTK51 VVGAQSLKEM 61 VSKLKKPRRI71 ILLVKAGQAV81 DDFIEKLVPL91 LDTGDIIIDG101 GNSEYRDTTR 111 RCRDLKAKGI121 LFVGSGVSGG131 EEGARYGPSL141 MPGGNKEAWP151 HIKTIFQGIA 161 AKVGTGEPCC171 DWVGDEGAGH181 FVKMVHNGIE191 YGDMQLICEA201 YHLMKDVLGM 211 AQDEMAQAFE221 DWNKTELDSF231 LIEITANILK241 FQDTDGKHLL251 PKIRDSAGQK 261 GTGKWTAISA271 LEYGVPVTLI281 GEAVFARCLS291 SLKDERIQAS301 KKLKGPQKFQ 311 FDGDKKSFLE321 DIRKALYASK331 IISYAQGFML341 LRQAATEFGW351 TLNYGGIALM 361 WRGGCIIRSV371 FLGKIKDAFD381 RNPELQNLLL391 DDFFKSAVEN401 CQDSWRRAVS 411 TGVQAGIPMP421 CFTTALSFYD431 GYRHEMLPAS441 LIQAQRDYFG451 AHTYELLAKP 461 GQFIHTNWTG471 HGGTVSSSSY481 NA
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell. 2012 Nov 13;22(5):585-600. | ||||
| REF 2 | Structure of Human Phosphogluconate Dehydrogenase in Complex with Nadph at 2.53A | ||||
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