Binding Site Information of Target
Target General Information | Top | ||||
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Target ID | T76024 | Target Info | |||
Target Name | Complement C1s component (C1S) | ||||
Synonyms | Complement component 1 subcomponent s; Complement C1s subcomponent; C1-esterase; C1 esterase | ||||
Target Type | Successful Target | ||||
Gene Name | C1S | ||||
Biochemical Class | Peptidase | ||||
UniProt ID |
Drug Binding Sites of Target | Top | |||||
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Ligand Name: N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid | Ligand Info | |||||
Structure Description | CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN COMPLEMENT C1S PROTEASE | PDB:1ELV | ||||
Method | X-ray diffraction | Resolution | 1.70 Å | Mutation | Yes | [1] |
PDB Sequence |
LDCGIPESIE
351 NGKVEDPEST361 LFGSVIRYTC371 EEPYYYMEGG383 GEYHCAGNGS393 WVNEVLGPEL 403 PKCVPVCGVP413 REPFIIGGSD428 ADIKNFPWQV438 FFDNPWAGGA448 LINEYWVLTA 458 AHVVEGNREP468 TMYVGSTSVQ478 KMLTPEHVFI495 HPGWKLLAVP505 EGRTNFDNDI 515 ALVRLKDPVK525 MGPTVSPICL535 PGTSSDYNLM545 DGDLGLISGW555 GRTEKRDRAV 565 RLKAARLPVA575 PLRKCKEVAY595 VFTPNMICAG605 GEKGMDSCKG615 DSGGAFAVQD 625 PNDKTKFYAA635 GLVSWGPQCG645 TYGLYTRVKN655 YVDWIMKTMQ665 ENS |
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References | Top | ||||
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REF 1 | Crystal structure of the catalytic domain of human complement c1s: a serine protease with a handle. EMBO J. 2000 Apr 17;19(8):1755-65. |
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