Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T75792 Target Info
Target Name Jumonji domain-containing protein 1C (JMJD1C)
Synonyms Thyroid receptor-interacting protein 8; TRIP8; TRIP-8; TR-interacting protein 8; Probable JmjC domain-containing histone demethylation protein 2C; KIAA1380; JHDM2C
Target Type Literature-reported Target
Gene Name JMJD1C
UniProt ID
JHD2C_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Ethylmercurithiosalicylic acid Ligand Info
Structure Description Crystal structure of the Jumonji domain of human Jumonji domain containing 1C protein PDB:2YPD
Method X-ray diffraction Resolution 2.10 Å Mutation No [1]
PDB Sequence
MIPHSWICEK
2165
HILWLKDYKN
2175
SSNWKLFKEC
2185
WKQGQPAVVS
2195
GVHKKMNISL
2205

WKAESISLDF
2215
GDHQADLLNC
2225
KDSIISNANV
2235
KEFWDGFEEV
2245
SKRETVVLKL
2261

KDWPSGEDFK
2271
TMMPARYEDL
2281
LKSLPLPEYC
2291
NPEGKFNLAS
2301
HLPGFFVRGP
2314

RLCSAYGVVA
2324
AKDHDIGTTN
2334
LHIEVSDVVN
2344
ILVYVGIAKG
2354
NGILSKAGIL
2364

KKFEEEDLDD
2374
ILRKRLKDSS
2384
EIPGALWHIY
2394
AGKDVDKIRE
2404
FLQKISKEQG
2414

HDPIRDQSWY
2430
VNKKLRQRLL
2440
EEYGVRTCTL
2450
IQFLGDAIVL
2460
PAGALHQVQN
2470

FHSCIQVTED
2480
FVSPEHLVES
2490
FHLTQEL
Residue
Distance (Å)
TRP2161
4.025
CYS2163
2.659
GLU2164
3.928
HIS2166
3.450
GLU2184
3.238
CYS2185
2.840
GLN2188
3.132
GLN2190
3.709
LEU2223
4.709
ASN2224
4.817
CYS2225
2.408
SER2228
4.260
LYS2260
3.289
LYS2262
3.781
ASP2263
2.962
ARG2315
4.479
LEU2316
4.733
CYS2317
2.625
GLY2331
3.168
Residue
Distance (Å)
THR2332
3.193
THR2333
3.139
ASN2334
3.654
ASN2344
4.020
TRP2391
4.582
ILE2393
3.603
TYR2394
4.671
ALA2395
3.899
LYS2397
4.404
ASP2398
4.653
ARG2446
3.370
THR2447
3.309
CYS2448
2.205
THR2449
4.887
HIS2466
4.023
VAL2468
3.762
GLN2476
3.168
THR2478
4.688
References  Top
REF 1 Crystal Structure of the Jumonji Domain of Human Jumonji Domain Containing 1C Protein

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