Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T75772 Target Info
Target Name Enteropeptidase (TMPRSS15)
Synonyms Transmembrane protease serine 15; TMPRSS15; Serine protease 7; Enterokinase
Target Type Patented-recorded Target
Gene Name TMPRSS15
Biochemical Class Peptidase
UniProt ID
ENTK_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: 4-Guanidinobenzoic acid Ligand Info
Structure Description ENTEROPEPTIDASE IN COMPLEX WITH COMPOUND 6 PDB:6ZOV
Method X-ray diffraction Resolution 2.19 Å Mutation Yes [1]
PDB Sequence
IVGGSDAKEG
10
AWPWVVGLYY
20
DDRLLCGASL
30
VSSDWLVSAA
40
HCVYGRNLEP
50

SKWTAILGLH
60
MKSNLTSPQT
70
VPRLIDEIVI
80
NPHYNRRRKD
90
NDIAMMHLEF
100

KVNYTDYIQP
110
ISLPEENQVF
120
PPGRNCSIAG
130
WGTVVYQGTT
140
ADILQEADVP
150

LLSNERCQQQ
160
MPEYNITENM
170
ICAGYEEGGI
180
DSCQGDSGGP
190
LMCQENNRWF
200

LAGVTSFGYE
210
CALPNRPGVY
220
ARVSRFTEWI
230
QSFL
Residue
Distance (Å)
HIS41
4.244
ASP181
3.125
SER182
3.484
CYS183
3.695
GLN184
3.388
GLY185
3.660
ASP186
4.403
SER187
1.457
THR205
3.736
SER206
3.892
Residue
Distance (Å)
PHE207
3.903
GLY208
3.570
TYR209
4.022
GLU210
2.747
CYS211
3.506
ALA212
4.372
ARG216
4.480
PRO217
4.222
GLY218
3.250
VAL219
4.619
References  Top
REF 1 Targeting Enteropeptidase with Reversible Covalent Inhibitors To Achieve Metabolic Benefits. J Pharmacol Exp Ther. 2020 Dec;375(3):510-521.

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