Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T75545 | Target Info | |||
| Target Name | Solute carrier family 12 member 6 (SLC12A6) | ||||
| Synonyms | SLC12A6; Electroneutral potassium-chloride cotransporter 3 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | SLC12A6 | ||||
| Biochemical Class | Cation-chloride cotransporter | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 2-[[(2~{R})-2-butyl-6,7-bis(chloranyl)-2-cyclopentyl-1-oxidanylidene-3~{H}-inden-5-yl]oxy]ethanoic acid | Ligand Info | |||||
| Structure Description | KCC3 bound with DIOA | PDB:6M22 | ||||
| Method | Electron microscopy | Resolution | 2.70 Å | Mutation | No | [1] |
| PDB Sequence |
YTNLTQGAKE
114 HEEQMGTFMG139 VYLPCLQNIF149 GVILFLRLTW159 VVGTAGVLQA169 FAIVLICCCC 179 TMLTAISMSA189 IATNGVVPAG199 GSYFMISRAL209 GPEFGGAVGL219 CFYLGTTFAA 229 AMYILGAIEI239 FLVYIVPRAA249 IFHSDDALKE259 SAAMLNNMRV269 YGTAFLVLMV 279 LVVFIGVRYV289 NKFASLFLAC299 VIVSILAIYA309 GAIKSSFAPP319 HFPVCMLGNR 329 TLSSRHIDVC339 SKTKEINNMT349 VPSKLWGFFC359 NSSQFFNATC369 DEYFVHNNVT 379 SIQGIPGLAS389 GIITENLWSN399 YLPKGEIIEK409 PSAKSSDVLG419 SLNHEYVLVD 429 ITTSFTLLVG439 IFFPSVTGIM449 AGSNRSGDLK459 DAQKSIPIGT469 ILAILTTSFV 479 YLSNVVLFGA489 CIEGVVLRDK499 FGDAVKGNLV509 VGTLSWPSPW519 VIVIGSFFST 529 CGAGLQSLTG539 APRLLQAIAK549 DNIIPFLRVF559 GHSKANGEPT569 WALLLTAAIA 579 ELGILIASLD589 LVAPILSMFF599 LMCYLFVNLA609 CALQTLLRTP619 NWRPRFRYYH 629 WALSFMGMSI639 CLALMFISSW649 YYAIVAMVIA659 GMIYKYIEYQ669 GAEKEWGDGI 679 RGLSLSAARF689 ALLRLEEGPP699 HTKNWRPQLL709 VLLKLDEDLH719 VKHPRLLTFA 729 SQLKAGKGLT739 IVGSVIVGNF749 LENYGEALAA759 EQTIKHLMEA769 EKVKGFCQLV 779 VAAKLREGIS789 HLIQSCGLGG799 MKHNTVVMGW809 PNGWRQSEDA819 RAWKTFIGTV 829 RVTTAAHLAL839 LVAKNISFFP849 SNVEQFSEGN859 IDVWWIVHDG869 GMLMLLPFLL 879 KQHKVWRKCS889 IRIFTVAQLE899 DNSIQMKKDL909 ATFLYHLRIE919 AEVEVVEMHD 929 SDISNVRRMH1034 TAVKLNEVIV1044 NKSHEAKLVL1054 LNMPGPPRNP1064 EGDENYMEFL 1074 EVLTEGLERV1084 LLVRGGGSEV1094 ITIYS
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Cryo-EM structures of the full-length human KCC2 and KCC3 cation-chloride cotransporters. Cell Res. 2021 Apr;31(4):482-484. | ||||
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