Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T75517 | Target Info | |||
| Target Name | Glutamine amidotransferase (GMPS) | ||||
| Synonyms | GMP synthetase; GMP synthase [glutamine-hydrolyzing] | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | GMPS | ||||
| Biochemical Class | Carbon-nitrogen ligase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Xanthosine-5'-monophosphate | Ligand Info | |||||
| Structure Description | Human GMP synthetase in complex with XMP | PDB:2VXO | ||||
| Method | X-ray diffraction | Resolution | 2.50 Å | Mutation | No | [1] |
| PDB Sequence |
EGAVVILDAG
34 YGKVIDRRVR46 ELFVQSEIFP56 LETPAFAIKE66 QGFRAIIISG76 GPAPWFDPAI 93 FTIGKPVLGI103 CYGMQMMNKV113 FGGTVHKVFN130 ISVDNTCSLF140 RGLQKEEVVL 150 LTHGDSVDKV160 ADGFKVVARS170 GNIVAGIANE180 SKKLYGAQFH190 PEVGLTENGK 200 VILKNFLYDI210 AGCSGTFTVQ220 NRELECIREI230 KERVGTSKVL240 VLLSGGVDST 250 VCTALLNRAL260 NQEQVIAVHI270 DNGFMRKRES280 QSVEEALKKL290 GIQVKVINAA 300 HSFYNGTTTL310 PRISKTLNMT330 TSPEEKRKII340 GDTFVKIANE350 VIGEMNLKPE 360 EVFLAQGTLR370 PDLIESASLV380 ASGKAELIKT390 HHNDTELIRK400 LREEGKVIEP 410 LKDFHKDEVR420 ILGRELGLPE430 ELVSRHPFPG440 PGLAIRVICA450 EEPYICKDFP 460 ETNNILKIVA470 DFSASVKKPH480 TLLQRVKACT490 TEEDQEKLMQ500 ITSLHSLNAF 510 LLPIKTVGVQ520 GDCRSYSYVC530 GISSKDEPDW540 ESLIFLARLI550 PRMCHNVNRV 560 VYIFGPPVKE570 PPTDVTPTFL580 TTGVLSTLRQ590 ADFEAHNILR600 ESGYAGKISQ 610 MPVILTPLHF620 DRDPLQKQPS630 CQRSVVIRTF640 ITSDFMTGIP650 ATPGNEIPVE 660 VVLKMVTEIK670 KIPGISRIMY680 DLTSKPPGTT690 EWE
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Substrate specificity and oligomerization of human GMP synthetase. J Mol Biol. 2013 Nov 15;425(22):4323-33. | ||||
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