Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T75273 | Target Info | |||
| Target Name | Staphylococcus DNA gyrase A (Stap-coc gyrA) | ||||
| Synonyms | Stap-coc DNA gyrase subunit A | ||||
| Target Type | Successful Target | ||||
| Gene Name | Stap-coc gyrA | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: N-[(4-chlorophenyl)methyl]-1-[2-(6-methoxy-1,5-naphthyridin-4-yl)ethyl]piperidin-4-amine | Ligand Info | |||||
| Structure Description | Ternary complex of Staphylococcus aureus DNA gyrase with AMK12 and DNA | PDB:6Z1A | ||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | Yes | [1] |
| PDB Sequence |
KLADCSSKSP
426 EECEIFLVEG436 DSAGGSTKSG446 RDSRTQAILP456 LRGKILNVEK466 ARLDRILNNN 476 EIRQMITAFG486 TGIGGDFDLA496 KARYHKIVIM506 TDADVDGAHI516 RTLLLTFFYR 526 FMRPLIEAGY536 VYIAQPPTGY580 KGLGEMNADQ590 LWETTMNPEH600 RALLQVKLED 610 AIEADQTFEM620 LMGDVVENRR630 QFIEDNAVYN1010 ERNITSEMRE1020 SFLDYAMSVI 1030 VARALPDVRD1040 GLKPVHRRIL1050 YGLNEQGMTP1060 DKSYKKSARI1070 VGDVMGKYHP 1080 HGDSSIYEAM1090 VRMAQDFSYR1100 YPLVDGQGNF1110 GSMDGDGAAA1120 MRFTEARMTK 1130 ITLELLRDIN1140 KDTIDFIDNY1150 DGNEREPSVL1160 PARFPNLLAN1170 GASGIAVGMA 1180 TNIPPHNLTE1190 LINGVLSLSK1200 NPDISIAELM1210 EDIEGPDFPT1220 AGLILGKSGI 1230 RRAYETGRGS1240 IQMRSRAVIE1250 ERGGGRQRIV1260 VTEIPFQVNK1270 ARMIEKIAEL 1280 VRDKKIDGIT1290 DLRDETSLRT1300 GVRVVIDVRK1310 DANASVILNN1320 LYKQTPLQTS 1330 FGVNMIALVN1340 GRPKLINLKE1350 ALVHYLEHQK1360 TVVRRRTQYN1370 LRKAKDRAHI 1380 LEGLRIALDH1390 IDEIISTIRE1400 SDTDKVAMES1410 LQQRFKLSEK1420 QAQAILDMRL 1430 RRLTGLERDK1440 IEAEYNELLN1450 YISELEAILA1460 DEEVLLQLVR1470 DELTEIRDRF 1480 GDDRRTEIQL1490 G
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Potent DNA gyrase inhibitors bind asymmetrically to their target using symmetrical bifurcated halogen bonds. Nat Commun. 2021 Jan 8;12(1):150. | ||||
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