Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T72514 Target Info
Target Name Interleukin-36 gamma (IL36G)
Synonyms IL-1-related protein 2; IL-1RP2; Interleukin-1 epsilon; IL-1 epsilon; Interleukin-1 family member 9; IL-1F9; Interleukin-1 homolog 1; IL-1H1
Target Type Clinical trial Target
Gene Name IL36G
UniProt ID
IL36G_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: (2S)-2-{[4-(3-amino-4-methylphenyl)-6-methylpyrimidin-2-yl]oxy}-3-methoxy-3,3-diphenylpropanoic acid Ligand Info
Structure Description Crystal structure of IL-36gamma complexed to A-552 PDB:6P9E
Method X-ray diffraction Resolution 2.00 Å Mutation No [1]
PDB Sequence
KPITGTINDL
30
NQQVWTLQGQ
40
NLVAVPRSDS
50
VTPVTVAVIT
60
CKYPEALEQG
70

RGDPIYLGIQ
80
NPEMCLYCEK
90
VGEQPTLQLK
100
EQKIMDLYGQ
110
PEPVKPFLFY
120

RAKTGRTSTL
130
ESVAFPDWFI
140
ASSKRDQPII
150
LTSELGKSYN
160
TAFELNIN
Residue
Distance (Å)
ILE23
3.861
ILE27
4.333
VAL58
3.999
THR60
3.313
ASP73
3.930
ILE75
3.928
ARG121
2.948
LYS123
2.793
Residue
Distance (Å)
ARG126
4.278
THR127
4.269
SER128
3.214
LEU130
4.169
PHE163
3.023
GLU164
3.974
LEU165
3.434
ILE167
3.709
References  Top
REF 1 Small Molecule IL-36Gamma Antagonist as a Novel Therapeutic Approach for Plaque Psoriasis. Sci Rep. 2019 Jun 24;9(1):9089.

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