Binding Site Information of Target

Content Navigation (  All   None )                                      
Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T72458 Target Info
Target Name Melanocortin receptor 4 (MC4R)
Synonyms MC4-R
Target Type Successful Target
Gene Name MC4R
Biochemical Class GPCR rhodopsin
UniProt ID
MC4R_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: THIQ Ligand Info
Structure Description Cryo-EM structure of THIQ-MC4R-Gs_Nb35 complex PDB:7F58
Method Electron microscopy Resolution 3.10 Å Mutation Yes [1]
PDB Sequence
GCYEQLFVSP
48
EVFVTLGVIS
58
LLENILVIVA
68
IAKNKNLHSP
78
MYFFICSLAV
88

ADMLVSVSNG
98
SETIVITLLN
108
STSFTVNIDN
123
VIDSVICSSL
133
LASICSLLSI
143

AVDRYFTIFY
153
ALQYHNIMTV
163
KRVGIIISCI
173
WAACTVSGIL
183
FIIYSDSSAV
193

IICLITMFFT
203
MLALMASLYV
213
HMFLMARLHI
223
KRIAVLPGTQ
237
GANMKGAITL
247

TILIGVFVVC
257
WAPFFLHLIF
267
YISCPQNPYC
277
VCFMSHFNLY
287
LILIMCNSII
297

DPLIYALRSQ
307
ELRKTFKEII
317
CCY
Residue
Distance (Å)
PHE45
3.380
PHE51
4.448
ASN97
3.977
GLU100
2.719
THR101
3.721
ILE104
3.547
ASN108
4.640
ASP122
4.804
ASP126
2.929
ILE129
3.590
CYS130
3.458
LEU133
3.959
PHE184
3.691
Residue
Distance (Å)
ILE185
4.059
SER188
3.579
VAL193
4.206
ILE194
3.701
LEU197
3.653
PHE261
3.409
HIS264
3.309
LEU265
3.371
TYR268
3.244
PHE284
3.359
ASN285
3.649
LEU288
3.811
References  Top
REF 1 Structural insights into ligand recognition and activation of the melanocortin-4 receptor. Cell Res. 2021 Nov;31(11):1163-1175.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.