Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T72195 Target Info
Target Name Annexin A5 (ANXA5)
Synonyms Vascular anticoagulantalpha; Vascular anticoagulant-alpha; VACalpha; VAC-alpha; Thromboplastin inhibitor; Placental anticoagulant protein I; Placental anticoagulant protein 4; PP4; PAPI; PAP-I; Lipocortin V; Endonexin II; ENX2; Calphobindin I; CBPI; CBP-I; Annexin5; Annexin-5; Annexin V; Anchorin CII; ANX5
Target Type Clinical trial Target
Gene Name ANXA5
Biochemical Class Annexin protein
UniProt ID
ANXA5_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: K201 free base Ligand Info
Structure Description CRYSTAL STRUCTURE OF RECOMBINANT HUMAN PLACENTAL ANNEXIN V COMPLEXED WITH K-201 AS A CALCIUM CHANNEL ACTIVITY INHIBITOR PDB:1HAK
Method X-ray diffraction Resolution 3.00 Å Mutation No [1]
PDB Sequence
QVLRGTVTDF
12
PGFDERADAE
22
TLRKAMKGLG
32
TDEESILTLL
42
TSRSNAQRQE
52

ISAAFKTLFG
62
RDLLDDLKSE
72
LTGKFEKLIV
82
ALMKPSRLYD
92
AYELKHALKG
102

AGTNEKVLTE
112
IIASRTPEEL
122
RAIKQVYEEE
132
YGSSLEDDVV
142
GDTSGYYQRM
152

LVVLLQANRD
162
PDAGIDEAQV
172
EQDAQALFQA
182
GELKWGTDEE
192
KFITIFGTRS
202

VSHLRKVFDK
212
YMTISGFQIE
222
ETIDRETSGN
232
LEQLLLAVVK
242
SIRSIPAYLA
252

ETLYYAMKGA
262
GTDDHTLIRV
272
MVSRSEIDLF
282
NIRKEFRKNF
292
ATSLYSMIKG
302

DTSGDYKKAL
312
LLLCGEDD
Residue
Distance (Å)
LEU5
3.691
ALA115
4.530
SER116
4.802
ARG117
4.387
THR118
3.487
PRO119
3.130
GLU121
2.996
ARG161
3.421
ASP164
4.706
VAL203
3.510
Residue
Distance (Å)
ARG207
3.305
SER243
3.002
ILE244
3.287
ARG245
4.686
SER246
4.613
ILE247
3.591
ARG276
3.281
ILE279
3.216
ASP280
4.737
References  Top
REF 1 Crystal structure of annexin V with its ligand K-201 as a calcium channel activity inhibitor. J Mol Biol. 1997 Nov 21;274(1):16-20.

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