Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T70449 Target Info
Target Name Growth hormone-releasing hormone receptor (GHRHR)
Synonyms GRFR; GRF receptor; GHRHR; GHRH receptor
Target Type Successful Target
Gene Name GHRHR
Biochemical Class GPCR secretin
UniProt ID
GHRHR_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Cholesterol Ligand Info
Structure Description Cryo-EM structure of the human growth hormone-releasing hormone receptor-Gs protein complex PDB:7CZ5
Method Electron microscopy Resolution 2.60 Å Mutation Yes [1]
PDB Sequence
LAEEESYFST
128
VKIIYTVGHS
138
ISIVALFVAI
148
TILVALRRLH
158
CPRNYVHTQL
168

FTTFILKAGA
178
VFLKDAALFH
188
SDDTDHCSFS
198
TVLCKVSVAA
208
SHFATMTNFS
218

WLLAEAVYLN
228
CLLASTSPSS
238
RRAFWWLVLA
248
GWGLPVLFTG
258
TWVSCKLAFE
268

DIACWDLDDT
278
SPYWWIIKGP
288
IVLSVGVNFG
298
LFLNIIRILV
308
RKLETQSQYW
325

RLSKSTLFLI
335
PLFGIHYIIF
345
NFLPDNAGLG
355
IRLPLELGLG
365
SFQGFIVAIL
375

YCFLNQEVRT
385
EISRKWHGH
Residue
Distance (Å)
TYR163
3.471
GLN167
3.746
THR170
4.181
LEU174
3.625
PHE211
3.574
Residue
Distance (Å)
PHE242
4.726
TRP243
4.274
VAL246
3.583
TRP250
3.262
References  Top
REF 1 Structural basis for activation of the growth hormone-releasing hormone receptor. Nat Commun. 2020 Oct 15;11(1):5205.

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