Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T70036 | Target Info | |||
| Target Name | Glutamate carboxypeptidase III (NAALAD2) | ||||
| Synonyms | NAALADase II; NAALAD2 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | NAALAD2 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: (2s)-2-{[(S)-[(3s)-3-Amino-3-Carboxypropyl](Hydroxy)phosphoryl]methyl}pentanedioic Acid | Ligand Info | |||||
| Structure Description | The high resolution structure of human glutamate carboxypeptidase III (GCPIII/NAALADase II) in complex with a transition state analog of Glu-Glu | PDB:3FED | ||||
| Method | X-ray diffraction | Resolution | 1.29 Å | Mutation | No | [1] |
| PDB Sequence |
SIRWKLVSEM
55 KAENIKSFLR65 SFTKLPHLAG75 TEQNFLLAKK85 IQTQWKKFGL95 DSAKLVHYDV 105 LLSYPNETNA115 NYISIVDEHE125 TEIFKTSPPP138 DGYENVTNIV148 PPYNAFSAQG 158 MPEGDLVYVN168 YARTEDFFKL178 EREMGINCTG188 KIVIARYGKI198 FRGNKVKNAM 208 LAGAIGIILY218 SDPADYFAPE228 VQPYPKGWNL238 PGTAAQRGNV248 LNLNGAGDPL 258 TPGYPAKEYT268 FRLDVEEGVG278 IPRIPVHPIG288 YNDAEILLRY298 LGGIAPPDKS 308 WKGALNVSYS318 IGPGFTGSSF329 RKVRMHVYNI339 NKITRIYNVV349 GTIRGSVEPD 359 RYVILGGHRD369 SWVFGAIDPT379 SGVAVLQEIA389 RSFGKLMSKG399 WRPRRTIIFA 409 SWDAEEFGLL419 GSTEWAEENV429 KILQERSIAY439 INSDSSIEGN449 YTLRVDCTPL 459 LYQLVYKLTK469 EIPSPDDGFE479 SKSLYESWLE489 KDPSPENKNL499 PRINKLGSGS 509 DFEAYFQRLG519 IASGRARYTK529 NKKTDKYSSY539 PVYHTIYETF549 ELVEKFYDPT 559 FKKQLSVAQL569 RGALVYELVD579 SKIIPFNIQD589 YAEALKNYAA599 SIYNLSKKHD 609 QQLTDHGVSF619 DSLFSAVKNF629 SEAASDFHKR639 LIQVDLNNPI649 AVRMMNDQLM 659 LLERAFIDPL669 GLPGKLFYRH679 IIFAPSSHNK689 YAGESFPGIY699 DAIFDIENKA 709 NSRLAWKEVK719 KHISIAAFTI729 QAAAGTLKEV739
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PHE199
4.155
ARG200
2.758
GLY246
4.748
ASN247
2.866
HIS367
3.264
TRP371
4.992
ASP377
3.000
GLU414
2.737
GLU415
3.284
PHE416
4.725
GLY417
3.314
LEU418
4.037
|
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| Ligand Name: 3[N-Morpholino]propane sulfonic acid | Ligand Info | |||||
| Structure Description | Crystal structure of human Glutamate Carboxypeptidase III (GCPIII/NAALADase II), pseudo-unliganded | PDB:3FEC | ||||
| Method | X-ray diffraction | Resolution | 1.49 Å | Mutation | No | [1] |
| PDB Sequence |
SIRWKLVSEM
55 KAENIKSFLR65 SFTKLPHLAG75 TEQNFLLAKK85 IQTQWKKFGL95 DSAKLVHYDV 105 LLSYPNETNA115 NYISIVDEHE125 TEIFKTSPPD139 GYENVTNIVP149 PYNAFSAQGM 159 PEGDLVYVNY169 ARTEDFFKLE179 REMGINCTGK189 IVIARYGKIF199 RGNKVKNAML 209 AGAIGIILYS219 DPADYFAPEV229 QPYPKGWNLP239 GTAAQRGNVL249 NLNGAGDPLT 259 PGYPAKEYTF269 RLDVEEGVGI279 PRIPVHPIGY289 NDAEILLRYL299 GGIAPPDKSW 309 KGALNVSYSI319 GPGFTGSSFR330 KVRMHVYNIN340 KITRIYNVVG350 TIRGSVEPDR 360 YVILGGHRDS370 WVFGAIDPTS380 GVAVLQEIAR390 SFGKLMSKGW400 RPRRTIIFAS 410 WDAEEFGLLG420 STEWAEENVK430 ILQERSIAYI440 NSDSSIEGNY450 TLRVDCTPLL 460 YQLVYKLTKE470 IPSPDDGFES480 KSLYESWLEK490 DPSPENKNLP500 RINKLGSGSD 510 FEAYFQRLGI520 ASGRARYTKN530 KKTDKYSSYP540 VYHTIYETFE550 LVEKFYDPTF 560 KKQLSVAQLR570 GALVYELVDS580 KIIPFNIQDY590 AEALKNYAAS600 IYNLSKKHDQ 610 QLTDHGVSFD620 SLFSAVKNFS630 EAASDFHKRL640 IQVDLNNPIA650 VRMMNDQLML 660 LERAFIDPLG670 LPGKLFYRHI680 IFAPSSHNKY690 AGESFPGIYD700 AIFDIENKAN 710 SRLAWKEVKK720 HISIAAFTIQ730 AAAGTLKEV
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| Ligand Name: CID 6971145 | Ligand Info | |||||
| Structure Description | The high resolution structure of human glutamate carboxypeptidase III (GCPIII/NAALADase II) in complex with quisqualic acid | PDB:3FEE | ||||
| Method | X-ray diffraction | Resolution | 1.56 Å | Mutation | No | [1] |
| PDB Sequence |
SIRWKLVSEM
55 KAENIKSFLR65 SFTKLPHLAG75 TEQNFLLAKK85 IQTQWKKFGL95 DSAKLVHYDV 105 LLSYPNETNA115 NYISIVDEHE125 TEIFKTSLEP136 PPDGYENVTN146 IVPPYNAFSA 156 QGMPEGDLVY166 VNYARTEDFF176 KLEREMGINC186 TGKIVIARYG196 KIFRGNKVKN 206 AMLAGAIGII216 LYSDPADYFA226 PEVQPYPKGW236 NLPGTAAQRG246 NVLNLNGAGD 256 PLTPGYPAKE266 YTFRLDVEEG276 VGIPRIPVHP286 IGYNDAEILL296 RYLGGIAPPD 306 KSWKGALNVS316 YSIGPGFTGS326 SFRKVRMHVY337 NINKITRIYN347 VVGTIRGSVE 357 PDRYVILGGH367 RDSWVFGAID377 PTSGVAVLQE387 IARSFGKLMS397 KGWRPRRTII 407 FASWDAEEFG417 LLGSTEWAEE427 NVKILQERSI437 AYINSDSSIE447 GNYTLRVDCT 457 PLLYQLVYKL467 TKEIPSPDDG477 FESKSLYESW487 LEKDPSPENK497 NLPRINKLGS 507 GSDFEAYFQR517 LGIASGRARY527 TKNDKYSSYP540 VYHTIYETFE550 LVEKFYDPTF 560 KKQLSVAQLR570 GALVYELVDS580 KIIPFNIQDY590 AEALKNYAAS600 IYNLSKKHDQ 610 QLTDHGVSFD620 SLFSAVKNFS630 EAASDFHKRL640 IQVDLNNPIA650 VRMMNDQLML 660 LERAFIDPLG670 LPGKLFYRHI680 IFAPSSHNKY690 AGESFPGIYD700 AIFDIENKAN 710 SRLAWKEVKK720 HISIAAFTIQ730 AAAGTLKEV
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .QUS or .QUS2 or .QUS3 or :3QUS;style chemicals stick;color identity;select .A:199 or .A:200 or .A:246 or .A:247 or .A:414 or .A:415 or .A:416 or .A:417 or .A:418 or .A:507 or .A:508 or .A:509 or .A:512 or .A:542 or .A:543 or .A:689 or .A:690; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III. FEBS J. 2009 Aug;276(16):4448-62. | ||||
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