Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T70027 Target Info
Target Name Torsin-1A (TOR1A)
Synonyms Torsin family 1 member A; Torsin ATPase-1A; TORA; TA; Dystonia 1 protein; DYT1; DQ2
Target Type Literature-reported Target
Gene Name TOR1A
Biochemical Class Acid anhydride hydrolase
UniProt ID
TOR1A_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Adenosine triphosphate Ligand Info
Structure Description TorsinA-LULL1 complex, H. sapiens, bound to VHH-BS2 PDB:5J1S
Method X-ray diffraction Resolution 1.40 Å Mutation Yes [1]
PDB Sequence
SLSREALQKD
64
LDDNLFGQHL
74
AKKIILNAVF
84
GFINNPKPKK
94
PLTLSLHGWT
104

GTGKNFVSKI
114
IAENIYEGGL
124
NSDYVHLFVA
134
TLHFPHASNI
144
TLYKDQLQLW
154

IRGNVSACAR
164
SIFIFDQMDK
174
MHAGLIDAIK
184
PFLDYYDLVD
194
GVSYQKAMFI
204

FLSNAGAERI
214
TDVALDFWRS
224
GKQREDIKLK
234
DIEHALSVSV
244
FNNKNSGFWH
254

SSLIDRNLID
264
YFVPFLPLEY
274
KHLKMCIRVE
284
MQSRGYEIDE
294
DIVSRVAEEM
304

TFFPKEERVF
314
SDKGCKTVFT
324
KLDYYYD
Residue
Distance (Å)
ASN68
3.323
LEU69
3.556
PHE70
2.855
GLN72
3.932
GLY102
4.644
TRP103
3.971
THR104
2.648
GLY105
2.934
THR106
2.902
GLY107
3.095
LYS108
2.720
Residue
Distance (Å)
ASN109
2.857
PHE110
2.951
LYS113
4.593
ASP170
4.936
GLN171
3.480
ASN208
2.896
LEU272
4.102
CYS280
3.674
CYS319
3.525
LYS320
2.993
PHE323
4.077
Click to View More Binding Site Information of This Target and Ligand Pair
References  Top
REF 1 Structures of TorsinA and its disease-mutant complexed with an activator reveal the molecular basis for primary dystonia. Elife. 2016 Aug 4;5. pii: e17983.

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