Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T69420 | Target Info | |||
| Target Name | Glutathione synthetase (GSS) | ||||
| Synonyms | Glutathione synthase; GSH-S; GSH synthetase | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | GSS | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Glutathione | Ligand Info | |||||
| Structure Description | HUMAN GLUTATHIONE SYNTHETASE | PDB:2HGS | ||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [1] |
| PDB Sequence |
TNWGSLLQDK
12 QQLEELARQA22 VDRALAEGVL32 LRTSQEPTSS42 EVVSYAPFTL52 FPSLVPSALL 62 EQAYAVQMDF72 NLLVDAVSQN82 AAFLEQTLSS92 TIKQDDFTAR102 LFDIHKQVLK 112 EGIAQTVFLG122 LNRSDYMFQR132 SADGSPALKQ142 IEINTISASF152 GGLASRTPAV 162 HRHVLSVLSK172 TKEAGKILSN182 NPSKGLALGI192 AKAWELYGSP202 NALVLLIAQE 212 KERNIFDQRA222 IENELLARNI232 HVIRRTFEDI242 SEKGSLDQDR252 RLFVDGQEIA 262 VVYFRDGYMP272 RQYSLQNWEA282 RLLLERSHAA292 KCPDIATQLA302 GTKKVQQELS 312 RPGMLEMLLP322 GQPEAVARLR332 ATFAGLYSLD342 VGEEGDQAIA352 EALAAPSRFV 362 LKPQREGGGN372 NLYGEEMVQA382 LKQLKDSEER392 ASYILMEKIE402 PEPFENCLLR 412 PGSPARVVQC422 ISELGIFGVY432 VRQEKTLVMN442 KHVGHLLRTK452 AIEHADGGVA 462 AGVAVLDNPY472 PV
|
|||||
|
|
ARG125
2.991
ASN146
3.968
ILE148
3.268
SER149
2.744
ALA150
3.642
SER151
2.685
PHE152
3.451
GLU214
2.450
ASN216
3.084
ASP219
4.776
|
|||||
| Ligand Name: adenosine diphosphate | Ligand Info | |||||
| Structure Description | HUMAN GLUTATHIONE SYNTHETASE | PDB:2HGS | ||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [1] |
| PDB Sequence |
TNWGSLLQDK
12 QQLEELARQA22 VDRALAEGVL32 LRTSQEPTSS42 EVVSYAPFTL52 FPSLVPSALL 62 EQAYAVQMDF72 NLLVDAVSQN82 AAFLEQTLSS92 TIKQDDFTAR102 LFDIHKQVLK 112 EGIAQTVFLG122 LNRSDYMFQR132 SADGSPALKQ142 IEINTISASF152 GGLASRTPAV 162 HRHVLSVLSK172 TKEAGKILSN182 NPSKGLALGI192 AKAWELYGSP202 NALVLLIAQE 212 KERNIFDQRA222 IENELLARNI232 HVIRRTFEDI242 SEKGSLDQDR252 RLFVDGQEIA 262 VVYFRDGYMP272 RQYSLQNWEA282 RLLLERSHAA292 KCPDIATQLA302 GTKKVQQELS 312 RPGMLEMLLP322 GQPEAVARLR332 ATFAGLYSLD342 VGEEGDQAIA352 EALAAPSRFV 362 LKPQREGGGN372 NLYGEEMVQA382 LKQLKDSEER392 ASYILMEKIE402 PEPFENCLLR 412 PGSPARVVQC422 ISELGIFGVY432 VRQEKTLVMN442 KHVGHLLRTK452 AIEHADGGVA 462 AGVAVLDNPY472 PV
|
|||||
|
|
MET129
3.846
ILE143
3.492
GLU144
3.021
ASN146
4.034
LYS305
2.904
VAL362
3.834
LYS364
2.606
ARG367
3.983
GLU368
2.820
GLY369
3.304
GLY370
2.671
GLY371
4.685
ASN372
4.357
|
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Molecular basis of glutathione synthetase deficiency and a rare gene permutation event. EMBO J. 1999 Jun 15;18(12):3204-13. | ||||
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