Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T68490 Target Info
Target Name Histone-lysine N-methyltransferase KMT5C (KMT5C)
Synonyms Lysine N-methyltransferase 5C; Lysine-specific methyltransferase 5C; Suppressor of variegation 4-20 homolog 2; Su(var)4-20 homolog 2; Suv4-20h2; [histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B; [histone H4]-lysine20 N-methyltransferase KMT5B
Target Type Preclinical Target
Gene Name KMT5C
UniProt ID
KMT5C_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Ademetionine Ligand Info
Structure Description Crystal structure of suppressor of variegation 4-20 homolog 2 PDB:3RQ4
Method X-ray diffraction Resolution 1.80 Å Mutation No [1]
PDB Sequence
DRVTARELCE
13
NDDLATSLVL
23
DPYLGFRTHK
33
MNVSPVPPLR
43
RQQHLRSALE
53

TFLRQRDLEA
63
AYRALTLGGW
73
TARYFQSRGP
83
RQEAALKTHV
93
YRYLRAFLPE
103

SGFTILPCTR
113
YSMETNGAKI
123
VSTRAWKKNE
133
KLELLVGCIA
143
ELREADEGLL
153

RAGENDFSIM
163
YSTRKRSAQL
173
WLGPAAFINH
183
DCKPNCKFVP
193
ADGNAACVKV
203

LRDIEPGDEV
213
TCFYGEGFFG
223
EKNEHCECHT
233
CERKGEGAFR
243
Residue
Distance (Å)
HIS32
2.594
TYR114
3.311
MET116
3.626
GLU117
2.753
ASN119
4.394
GLY120
3.473
ALA121
2.893
PHE160
3.130
SER161
3.884
ALA179
3.290
PHE180
3.695
Residue
Distance (Å)
ILE181
3.526
ASN182
2.813
HIS183
2.924
ASP184
4.796
TYR217
3.342
PHE222
3.443
HIS228
4.501
CYS229
3.405
GLU230
3.000
CYS231
3.624
References  Top
REF 1 Crystal structures of the human histone H4K20 methyltransferases SUV420H1 and SUV420H2. FEBS Lett. 2013 Nov 29;587(23):3859-68.

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