Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T67942 Target Info
Target Name Bacterial Cystathionine gamma-synthase (Bact metB)
Synonyms metB; O-succinylhomoserine (Thiol)-lyase; CGS
Target Type Literature-reported Target
Gene Name Bact metB
Biochemical Class Alkyl aryl transferase
UniProt ID
METB_ECOLI
Drug Binding Sites of Target  Top
Ligand Name: N6-((3-Hydroxy-2-methyl-5-((phosphonooxy)methyl)-4-pyridinyl)methylene)-L-lysine Ligand Info
Structure Description CYSTATHIONINE GAMMA-SYNTHASE (CGS) FROM ESCHERICHIA COLI PDB:1CS1
Method X-ray diffraction Resolution 1.50 Å Mutation Yes [1]
PDB Sequence
RKQATIAVRS
12
GLNDDEQYGC
22
VVPPIHLSST
32
YNFTGFNEPR
42
AHDYSRRGNP
52

TRDVVQRALA
62
ELEGGAGAVL
72
TNTGMSAIHL
82
VTTVFLKPGD
92
LLVAPHDCYG
102

GSYRLFDSLA
112
KRGCYRVLFV
122
DQGDEQALRA
132
ALAEKPKLVL
142
VESPSNPLLR
152

VVDIAKICHL
162
AREVGAVSVV
172
DNTFLSPALQ
182
NPLALGADLV
192
LHSCTYLNGH
203

SDVVAGVVIA
213
KDPDVVTELA
223
WWANNIGVTG
233
GAFDSYLLLR
243
GLRTLVPRME
253

LAQRNAQAIV
263
KYLQTQPLVK
273
KLYHPSLPEN
283
QGHEIAARQQ
293
KGFGAMLSFE
303

LDGDEQTLRR
313
FLGGLSLFTL
323
AESLGGVESL
333
ISHAATMTHA
343
GMAPEARAAA
353

GISETLLRIS
363
TGIEDGEDLI
373
ADLENGFRAA
383
NKG
Residue
Distance (Å)
THR75
3.481
GLY76
2.854
MET77
2.794
ILE80
3.844
TYR101
3.450
SER104
4.823
GLU144
3.587
ASP173
2.699
THR175
3.572
PHE176
4.121
SER195
2.847
CYS196
2.986
Residue
Distance (Å)
THR197
1.325
TYR199
1.327
LEU200
3.429
ASN201
3.655
GLY202
2.878
HIS203
4.765
VAL207
4.402
ALA208
3.940
SER326
3.355
LEU327
3.407
GLY328
3.725
GLY329
4.587
References  Top
REF 1 Crystal structure of Escherichia coli cystathionine gamma-synthase at 1.5 A resolution. EMBO J. 1998 Dec 1;17(23):6827-38.

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