Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T67894 | Target Info | |||
| Target Name | Toll-like receptor 3 (TLR3) | ||||
| Synonyms | CD283 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | TLR3 | ||||
| Biochemical Class | Toll-like receptor | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: (2S,3R,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol | Ligand Info | |||||
| Structure Description | The molecular structure of toll-like receptor 3 ligand binding domain | PDB:2A0Z | ||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | No | [1] |
| PDB Sequence |
TKCTVSHEVA
35 DCSHLKLTQV45 PDDLPTNITV55 LNLTHNQLRR65 LPAANFTRYS75 QLTSLDVGFN 85 TISKLEPELC95 QKLPMLKVLN105 LQHNELSQLS115 DKTFAFCTNL125 TELHLMSNSI 135 QKIKNNPFVK145 QKNLITLDLS155 HNGLSSTKLG165 TQVQLENLQE175 LLLSNNKIQA 185 LKSEELDIFA195 NSSLKKLELS205 SNQIKEFSPG215 CFHAIGRLFG225 LFLNNVQLGP 235 SLTEKLCLEL245 ANTSIRNLSL255 SNSQLSTTSN265 TTFLGLKWTN275 LTMLDLSYNN 285 LNVVGNDSFA295 WLPQLEYFFL305 EYNNIQHLFS315 HSLHGLFNVR325 YLNLKRSFTK 335 QSISLASLPK345 IDDFSFQWLK355 CLEHLNMEDN365 DIPGIKSNMF375 TGLINLKYLS 385 LSNSFTSLRT395 LTNETFVSLA405 HSPLHILNLT415 KNKISKIESD425 AFSWLGHLEV 435 LDLGLNEIGQ445 ELTGQEWRGL455 ENIFEIYLSY465 NKYLQLTRNS475 FALVPSLQRL 485 MLRRVALKNV495 DSSPSPFQPL505 RNLTILDLSN515 NNIANINDDM525 LEGLEKLEIL 535 DLQHNNLARL545 WKHANPGGPI555 YFLKGLSHLH565 ILNLESNGFD575 EIPVEVFKDL 585 FELKIIDLGL595 NNLNTLPASV605 FNNQVSLKSL615 NLQKNLITSV625 EKKVFGPAFR 635 NLTELDMRFN645 PFDCTCESIA655 WFVNWINETH665 TNIPELSSHY675 LCNTPPHYHG 685 FPVRLFDTSS695 C
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The molecular structure of the Toll-like receptor 3 ligand-binding domain. Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):10976-80. | ||||
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