Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T67812 | Target Info | |||
| Target Name | Mannoside acetylglucosaminyltransferase 2 (MGAT2) | ||||
| Synonyms | N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II; GlcNAc-T II; GNT-II; Beta-1,2-N-acetylglucosaminyltransferase II; Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | ||||
| Target Type | Patented-recorded Target | ||||
| Gene Name | MGAT2 | ||||
| Biochemical Class | Glycosyltransferases | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Uridine-5'-Diphosphate | Ligand Info | |||||
| Structure Description | Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase with bound UDP and Manganese | PDB:5VCM | ||||
| Method | X-ray diffraction | Resolution | 1.60 Å | Mutation | No | [1] |
| PDB Sequence |
NLTLRYRSLV
95 YQLNFDQTLR105 NVDWAPRELV119 LVVQVHNRPE129 YLRLLLDSLR139 KAQGIDNVLV 149 IFSHDFWSTE159 INQLIAGVNF169 CPVLQVFFPF179 SIQLYPNEFP189 GSDPRDCPRD 199 LPKNAALKLG209 CINAEYPDSF219 GHYREAKFSQ229 TKHHWWWKLH239 FVWERVKILR 249 DYAGLILFLE259 EDHYLAPDFY269 HVFKKMWKLK279 QQECPECDVL289 SLGTYSSRSF 300 YGMADKVDVK310 TWKSTEHNMG320 LALTRNAYQK330 LIECTDTFCT340 YDDYNWDWTL 350 QYLTVSCLPK360 FWKVLVPQIP370 RIFHAGDCGC386 RPSTQSAQIE396 SLLNNNKQYM 406 FPETLTISEK416 FTVVAISPPR426 KNGGWGDIRD436 HELCKSYRRL446 Q |
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Human N-acetylglucosaminyltransferase II substrate recognition uses a modular architecture that includes a convergent exosite. Proc Natl Acad Sci U S A. 2018 May 1;115(18):4637-4642. | ||||
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