Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T67710 Target Info
Target Name Parathyroid hormone 1 receptor (PTH1R)
Synonyms Parathyroid hormone-related peptide (PTHRP); PTH1R; PTH/PTHrP type I receptor; PTH/PTHr receptor
Target Type Successful Target
Gene Name PTH1R
Biochemical Class GPCR secretin
UniProt ID
PTH1R_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Cholesterol Ligand Info
Structure Description Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid hormone analog and G protein PDB:6NBF
Method Electron microscopy Resolution 3.00 Å Mutation Yes [1]
PDB Sequence
VMTKEEQIFL
40
LHRAQAQCEK
50
RLKEVGRPCL
109
PEWDHILCWP
119
LGAPGEVVAV
129

PCPDYIYDFN
139
HKGHAYRRCD
149
RNGSWELVPG
159
HNRTWANYSE
169
CVKFLTNETR
179

EREVFDRLAM
189
IYTVGYSVSL
199
ASLTVAVLIL
209
AYFRRLHCTR
219
NYIHMHLFLS
229

FMLRAVSIFV
239
KDAVLYSAGY
278
AGCRVAVTFF
288
LYFLATNYYW
298
ILVEGLYLHS
308

LIFMAFFSEK
318
KYLWGFTVFG
328
WGLPAVFVAV
338
WVSVRATLAN
348
TGCWDLSSGN
358

KKWIIQVPIL
368
ASIVLNFILF
378
INIVRVLATK
388
LRETNTRQQY
403
RKLLKSTLVL
413

MPLFGVHYIV
423
FMATPYTEVS
433
GTLWQVQMHY
443
EMLFNSFQGF
453
FVAIIYCFCN
463

GEVQAEIKKS
473
WSRWTLAL
Residue
Distance (Å)
HIS225
3.502
LEU232
3.927
ALA279
3.736
ARG282
3.599
VAL283
3.689
THR286
3.734
PHE287
3.665
TYR290
4.083
PHE291
3.798
TRP322
4.046
THR325
4.017
TRP329
3.562
ALA333
4.650
PHE335
4.039
VAL340
3.671
ASN348
4.805
TRP352
4.122
ASN358
3.263
LYS359
4.365
TRP361
3.609
Residue
Distance (Å)
ILE362
3.710
VAL365
4.156
PRO366
3.909
LEU368
3.657
ALA369
3.699
VAL372
4.394
PHE375
3.992
ILE422
3.498
VAL423
4.076
ALA426
3.257
THR427
3.776
PRO428
3.408
LEU436
4.053
GLN438
3.228
VAL439
3.653
HIS442
3.758
TYR443
4.083
LEU446
3.766
PHE447
3.663
Click to View More Binding Site Information of This Target and Ligand Pair
References  Top
REF 1 Structure and dynamics of the active human parathyroid hormone receptor-1. Science. 2019 Apr 12;364(6436):148-153.

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