Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T66350 Target Info
Target Name Ras-related protein Rab-9A (RAB9A)
Synonyms RAB9A
Target Type Successful Target
Gene Name RAB9A
Biochemical Class Small GTPase superfamily
UniProt ID
RAB9A_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Guanosine-5'-Triphosphate Ligand Info
Structure Description Crystal structure of Rab9A-GTP-Nde1 PDB:7E1T
Method X-ray diffraction Resolution 2.45 Å Mutation Yes [1]
PDB Sequence
SLFKVILLGD
15
GGVGKSSLMN
25
RYVTNKFDTQ
35
LFHTIGVEFL
45
NKDLEVDGHF
55

VTMQIWDTAG
65
LERFRSLRTP
75
FYRGSDCCLL
85
TFSVDDSQSF
95
QNLSNWKKEF
105

IYYADVKEPE
115
SFPFVILGNK
125
IDISERQVST
135
EEAQAWCRDN
145
GDYPYFETSA
155

KDATNVAAAF
165
EEAVRRVLAT
175
Residue
Distance (Å)
GLY14
4.475
ASP15
3.598
GLY16
3.152
GLY17
2.419
VAL18
3.191
GLY19
3.033
LYS20
2.456
SER21
3.372
SER22
3.067
PHE32
3.600
ASP33
3.432
THR34
2.600
GLN35
4.361
LEU36
3.907
PHE37
4.367
Residue
Distance (Å)
HIS38
2.551
THR39
2.977
THR63
4.029
ALA64
3.933
GLY65
2.921
LEU66
3.973
ASN124
3.297
LYS125
2.833
ASP127
2.223
ILE128
3.602
THR153
4.742
SER154
3.493
ALA155
2.827
LYS156
3.162
Ligand Name: Guanosine-5'-Diphosphate Ligand Info
Structure Description High resolution crystal structure of human Rab9 GTPase: a novel antiviral drug target PDB:1WMS
Method X-ray diffraction Resolution 1.25 Å Mutation No [2]
PDB Sequence
AGKSSLFKVI
11
LLGDGGVGKS
21
SLMNRYVTNK
31
FDTTIGVEFL
45
NKDLEVDGHF
55

VTMQIWDTAG
65
QERFRSLRTP
75
FYRGSDCCLL
85
TFSVDDSQSF
95
QNLSNWKKEF
105

IYYADVKEPE
115
SFPFVILGNK
125
IDISERQVST
135
EEAQAWCRDN
145
GDYPYFETSA
155

KDATNVAAAF
165
EEAVRRVLAT
175
Residue
Distance (Å)
ASP15
3.829
GLY16
3.847
GLY17
2.828
VAL18
3.325
GLY19
2.954
LYS20
2.805
SER21
2.909
SER22
2.676
PHE32
3.233
THR34
3.024
Residue
Distance (Å)
ASP62
4.159
ASN124
3.246
LYS125
3.044
ASP127
2.825
ILE128
3.740
THR153
4.707
SER154
3.354
ALA155
2.860
LYS156
3.279
References  Top
REF 1 Nde1 is a Rab9 effector for loading late endosomes to cytoplasmic dynein motor complex. Structure. 2022 Mar 3;30(3):386-395.e5.
REF 2 High resolution crystal structure of human Rab9 GTPase: a novel antiviral drug target. J Biol Chem. 2004 Sep 17;279(38):40204-8.

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