Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T66120 | Target Info | |||
| Target Name | Bacterial Deoxy-manno-octulosonate cytidylyltransferase (Bact kdsB) | ||||
| Synonyms | kdsB; CMP-KDO synthetase; CMP-2-keto-3-deoxyoctulosonic acid synthetase; CKS; 3-deoxy-D-manno-octulosonate cytidylytransferase | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | Bact kdsB | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: CTP | Ligand Info | |||||
| Structure Description | Crystal structure of E. coli lipopolysaccharide specific CMP-KDO synthetase in complex with CTP and 2-deoxy-Kdo | PDB:3K8D | ||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [1] |
| PDB Sequence |
SFVVIIPARY
11 ASTRLPGKPL21 VDINGKPMIV31 HVLERARESG41 AERIIVATDH51 EDVARAVEAA 61 GGEVCMTRAD71 HQSGTERLAE81 VVEKCAFSDD91 TVIVNVQGDE101 PMIPATIIRQ 111 VADNLAQRQV121 GMATLAVPIH131 NAEEAFNPNA141 VKVVLDAEGY151 ALYFSRATIP 161 WDRDRFAEGL171 ETVGDNFLRH181 LGIYGYRAGF191 IRRYVNWQPS201 PLEHIEMLEQ 211 LRVLWYGEKI221 HVAVAQEVPG231 TGVDTPEDLE241 RVRAEM
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| Ligand Name: 3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid | Ligand Info | |||||
| Structure Description | Crystal structure of E. coli lipopolysaccharide specific CMP-KDO synthetase in complex with CTP and 2-deoxy-Kdo | PDB:3K8D | ||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [1] |
| PDB Sequence |
SFVVIIPARY
11 ASTRLPGKPL21 VDINGKPMIV31 HVLERARESG41 AERIIVATDH51 EDVARAVEAA 61 GGEVCMTRAD71 HQSGTERLAE81 VVEKCAFSDD91 TVIVNVQGDE101 PMIPATIIRQ 111 VADNLAQRQV121 GMATLAVPIH131 NAEEAFNPNA141 VKVVLDAEGY151 ALYFSRATIP 161 WDRDRFAEGL171 ETVGDNFLRH181 LGIYGYRAGF191 IRRYVNWQPS201 PLEHIEMLEQ 211 LRVLWYGEKI221 HVAVAQEVPG231 TGVDTPEDLE241 RVRAEM
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure-based mechanism of CMP-2-keto-3-deoxymanno-octulonic acid synthetase: convergent evolution of a sugar-activating enzyme with DNA/RNA polymerases. J Biol Chem. 2009 Dec 18;284(51):35514-23. | ||||
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