Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T65879 | Target Info | |||
| Target Name | Inhibitor of nuclear factor kappa-B kinase alpha (IKKA) | ||||
| Synonyms | Transcription factor 16; TCF16; TCF-16; Nuclear factor NFkappaB inhibitor kinase alpha; Nuclear factor NF-kappa-B inhibitor kinase alpha; NFKBIKA; Inhibitory kappa B kinasea; Inhibitor of nuclear factor kappa-B kinase subunit alpha; IkappaB kinase A; IkBKA; IKK1; IKK-alpha; IKK-A; I-kappa-B kinase alpha; I-kappa-B kinase 1; I kappa-B kinase alpha; Conserved helix-loop-helix ubiquitous kinase | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | CHUK | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 2-Azanyl-5-Phenyl-3-(4-Sulfamoylphenyl)benzamide | Ligand Info | |||||
| Structure Description | Crystal structure of human IKK1 | PDB:5EBZ | ||||
| Method | X-ray diffraction | Resolution | 4.50 Å | Mutation | Yes | [1] |
| PDB Sequence |
DPEFGAGGPW
15 EMRERLGTGG25 FGNVCLYQHR35 ELDLKIAIKS45 CRLELSTKNR55 ERWCHEIQIM 65 KKLNHANVVK75 ACDVPEELNI85 LIHDVPLLAM95 EYCSGGDLRK105 LLNKPENCCG 115 LKESQILSLL125 SDIGSGIRYL135 HENKIIHRDL145 KPENIVLQDV155 GGKIIHKIID 165 LGYAKDVDQG175 ELCTEFVGTL185 QYLAPELFEN195 KPYTATVDYW205 SFGTMVFECI 215 AGYRPFLHHL225 QPFTWHEKIK235 KKDPKCIFAC245 EEMSGEVRFS255 SHLPQPNSLC 265 SLIVEPMENW275 LQLMLNWDPQ285 QRGGPVDLTL295 KQPRCFVLMD305 HILNLKIVHI 315 LNMTSAKIIS325 FLLPPDESLH335 SLQSRIERET345 GINTGSQELL355 SETGISLDPR 365 KPASQCVLDG375 VRGCDSYMVY385 LFDKSKTVYE395 GPFASRSLSD405 CVNYIVQDSK 415 IQLPIIQLRK425 VWAEAVHYVS435 GLKEDYSRLF445 QGQRAAMLSL455 LRYNANLTKM 465 KNTLISASQQ475 LKAKLEFFHK485 SIQLDLERYS495 EQMTYGISSE505 KMLKAWKEME 515 EKAIHYAEVG525 VIGYLEDQIM535 SLHAEIMELQ545 KSPYGRRQGD555 LMESLEQRAI 565 DLYKQLKHRP575 SDHSYSDSTE585 MVKIIVHTVQ595 SQDRVLKELF605 GHLSKLLGCK 615 QKIIDLLPKV625 EVALSNIKEA635 DNTVMFMQGK645 RQKEIWHLLK655 IACTQ |
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural Basis for the Activation of IKK1/Alpha. Cell Rep. 2016 Nov 15;17(8):1907-1914. | ||||
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