Binding Site Information of Target

Content Navigation (  All   None )                                      
Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T65019 Target Info
Target Name Matrix metalloproteinase-14 (MMP-14)
Synonyms Membrane-type-1 matrix metalloproteinase; Membrane-type matrix metalloproteinase 1; MTMMP1; MT1MMP; MT1-MMP; MT-MMP 1; MMP-X1
Target Type Clinical trial Target
Gene Name MMP14
Biochemical Class Peptidase
UniProt ID
MMP14_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: 1,2-Dimyristoyl-sn-glycero-3-phosphocholine Ligand Info
Structure Description MT1-MMP HPX Domain with Blade 2 Loop Bound to Nanodiscs PDB:6CM1
Method Solution NMR Resolution N.A. Mutation No [1]
PDB Sequence
PNICDGNFDT
325
VAMLRGEMFV
335
FKERWFWRVR
345
NNQVMDGYPM
355
PIGQFWRGLP
365

ASINTAYERK
375
DGKFVFFKGD
385
KHWVFDEASL
395
EPGYPKHIKE
405
LGRGLPTDKI
415

DAALFWMPNG
425
KTYFFRGNKY
435
YRFNEELRAV
445
DSEYPKNIKV
455
WEGIPESPRG
465

SFMGSDEVFT
475
YFYKGNKYWK
485
FNNQKLKVEP
495
GYPKSALRDW
505
MGCPSG
Residue
Distance (Å)
ARG330
3.444
GLY358
2.981
GLN359
1.719
PHE360
1.914
TRP361
2.386
ARG362
1.665
GLY363
4.787
ARG374
2.718
ASP376
4.852
LYS378
2.855
LYS386
3.569
ASP391
4.241
GLU392
2.005
ALA393
2.401
SER394
1.841
Residue
Distance (Å)
LEU395
3.906
GLU396
4.643
PRO397
2.573
GLY398
2.392
TYR399
1.742
PRO400
2.472
LYS401
1.658
HIS402
1.981
LYS404
3.420
GLU405
2.265
LEU406
3.982
GLY407
4.468
ARG408
2.696
LEU442
2.610
ARG443
1.721
References  Top
REF 1 MT1-MMP Binds Membranes by Opposite Tips of Its beta Propeller to Position It for Pericellular Proteolysis. Structure. 2019 Feb 5;27(2):281-292.e6.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.