Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T65005 Target Info
Target Name Hyperpolarization cyclic nucleotide-gated channel 2 (HCN2)
Synonyms Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2; Brain cyclic nucleotide-gated channel 2; BCNG2; BCNG-2
Target Type Literature-reported Target
Gene Name HCN2
Biochemical Class Voltage-gated ion channel
UniProt ID
HCN2_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: [3H]cAMP Ligand Info
Structure Description Tetramerization dynamics of the C-terminus underlies isoform-specific cAMP-gating in HCN channels PDB:3U10
Method X-ray diffraction Resolution 2.30 Å Mutation No [1]
PDB Sequence
DSSRRQYQEK
479
YKQVEQYMSF
489
HKLPADFRQK
499
IHDYYEHRYQ
509
GKMFDEDSIL
519

GELNGPLREE
529
IVNFNCRKLV
539
ASMPLFANAD
549
PNFVTAMLTK
559
LKFEVFQPGD
569

YIIREGTIGK
579
KMYFIQHGVV
589
SVLTKGNKEM
599
KLSDGSYFGE
609
ICLLTRGRRT
619

ASVRADTYCR
629
LYSLSVDNFN
639
EVLEEYPMMR
649
RAFETVAIDR
659
LDRIGKKNSI
669

LL
Residue
Distance (Å)
ILE572
4.044
VAL591
3.578
MET599
3.429
LEU601
4.057
TYR606
4.613
PHE607
3.392
GLY608
3.047
GLU609
2.479
ILE610
3.450
CYS611
2.963
Residue
Distance (Å)
LEU612
4.816
ARG617
4.299
ARG618
2.919
THR619
2.815
ALA620
3.299
VAL622
4.043
ARG659
2.860
LEU660
4.743
ARG662
3.792
ILE663
3.634
References  Top
REF 1 Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels. J Biol Chem. 2011 Dec 30;286(52):44811-20.

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