Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T64410 | Target Info | |||
| Target Name | Bacterial DD-carboxypeptidase (Bact vanYB) | ||||
| Synonyms | vanYB; DD-peptidase; DD-carboxypeptidase; D-alanyl-D-alanine carboxypeptidase-transpeptidase | ||||
| Target Type | Successful Target | ||||
| Gene Name | Bact vanYB | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: D-Alanine | Ligand Info | |||||
| Structure Description | VanYB in complex with D-Alanine-D-Alanine | PDB:5ZHW | ||||
| Method | X-ray diffraction | Resolution | 2.18 Å | Mutation | No | [1] |
| PDB Sequence |
EWSLILVNRQ
97 NPIPAQYDVE107 LEQLSNGERI117 DIRISPYLQD127 LFDAARADGV137 YPIVASGYRT 147 TEKQQEIDEK158 VAEYKAKGYT168 SAQAKAEAET178 WVAVPGTSEH188 QLGLAVDINA 198 DGIHSTGNEV208 YRWLDENSYR218 FGFIRRYPPD228 KTEITGVSNE238 PWHYRYVGIE 248 AATKIYHQGL258 CLEEYLNTEK268
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Selenomethionine | Ligand Info | |||||
| Structure Description | VanYB in complex with D-Alanine-D-Alanine | PDB:5ZHW | ||||
| Method | X-ray diffraction | Resolution | 2.18 Å | Mutation | No | [1] |
| PDB Sequence |
EWSLILVNRQ
97 NPIPAQYDVE107 LEQLSNGERI117 DIRISPYLQD127 LFDAARADGV137 YPIVASGYRT 147 TEKQQEIDEK158 VAEYKAKGYT168 SAQAKAEAET178 WVAVPGTSEH188 QLGLAVDINA 198 DGIHSTGNEV208 YRWLDENSYR218 FGFIRRYPPD228 KTEITGVSNE238 PWHYRYVGIE 248 AATKIYHQGL258 CLEEYLNTEK268
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural basis for the substrate recognition of peptidoglycan pentapeptides by Enterococcus faecalis VanY(B). Int J Biol Macromol. 2018 Nov;119:335-344. | ||||
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