Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T63846 Target Info
Target Name IL-1 receptor-associated kinase 1 (IRAK1)
Synonyms Interleukin-1 receptor-associated kinase 1; IRAK-1; IRAK
Target Type Patented-recorded Target
Gene Name IRAK1
Biochemical Class Kinase
UniProt ID
IRAK1_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: IRAK4 inhibitor 4b Ligand Info
Structure Description Crystal structure of human IRAK1 PDB:6BFN
Method X-ray diffraction Resolution 2.26 Å Mutation No [1]
PDB Sequence
SRPFPFCWPL
202
CEISRGTHNF
212
SEELKIGEGG
222
FGCVYRAVMR
232
NTVYAVKRLK
242

EWTAVKQSFL
257
TEVEQLSRFR
267
HPNIVDFAGY
277
CAQNGFYCLV
287
YGFLPNGSLE
297

DRLHCQTQAC
307
PPLSWPQRLD
317
ILLGTARAIQ
327
FLHQDSPSLI
337
HGDIKSSNVL
347

LDERLTPKLG
357
DFGLARFSRT
383
VRGTLAYLPE
393
EYIKTGRLAV
403
DTDTFSFGVV
413

VLETLAGQRA
423
VKTHGARTKY
433
LKDLVEEEAE
443
EAGVAAADAW
465
AAPIAMQIYK
475

KHLDPRPGPC
485
PPELGLGLGQ
495
LACCCLHRRA
505
KRRPPMTQVY
515
ERLEKLQAVV
525

A
Residue
Distance (Å)
ILE218
3.473
GLY219
4.101
PHE223
3.735
VAL226
3.841
ALA237
3.476
LYS239
3.876
VAL272
4.000
TYR288
3.565
GLY289
3.799
PHE290
3.634
LEU291
3.040
Residue
Distance (Å)
PRO292
3.469
ASN293
4.440
GLY294
3.497
SER295
4.465
ASP298
4.065
GLN305
4.947
SER344
4.491
ASN345
4.869
LEU347
3.226
GLY357
4.877
ASP358
2.691
References  Top
REF 1 Crystal structure of human IRAK1. Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):13507-13512.

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