Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T63803 Target Info
Target Name Vascular endothelial growth factor D (VEGFD)
Synonyms c-Fos-induced growth factor; VEGFD; VEGF-D; FIGF
Target Type Clinical trial Target
Gene Name VEGFD
Biochemical Class Growth factor
UniProt ID
VEGFD_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Alpha-D-Mannose Ligand Info
Structure Description Crystal structure of vascular endothelial growth factor D PDB:2XV7
Method X-ray diffraction Resolution 2.90 Å Mutation Yes [1]
PDB Sequence
PTFYDIETLK
100
VIDEEWQRTQ
110
CSPRETAVEV
120
ASELGKSTNT
130
FFKPPCVNVF
140

RCGGCCNEES
150
LICMNTSTSY
160
ISKQLFEISV
170
PLTSVPELVP
180
VKVANHTGCK
190

CLPT
Residue
Distance (Å)
GLU123
4.921
LEU124
2.908
Residue
Distance (Å)
GLY125
3.552
References  Top
REF 1 Structural determinants of vascular endothelial growth factor-D receptor binding and specificity. Blood. 2011 Feb 3;117(5):1507-15.

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