Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T63682 Target Info
Target Name TAO kinase 3 (TAOK3)
Synonyms hKFC-A; Thousand and one amino acid protein 3; Serine/threonine-protein kinase TAO3; MAP3K18; Kinase from chicken homolog A; KDS; Jun kinase-inhibitory kinase; JNK/SAPK-inhibitory kinase; JIK; Dendritic cell-derived protein kinase; DPK; Cutaneous T-cell lymphoma-associated antigen HD-CL-09; CTCL-associated antigen HD-CL-09
Target Type Literature-reported Target
Gene Name TAOK3
UniProt ID
TAOK3_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: adenosine diphosphate Ligand Info
Structure Description Crystal structure of human TAO3 kinase binding ADP PDB:6BDN
Method X-ray diffraction Resolution 1.50 Å Mutation Yes [1]
PDB Sequence
DPEIADLFYK
17
DDPEELFIGL
27
HEIGHGSFGA
37
VYFATNAHTS
47
EVVAIKKMSY
57

SGKQTHEKWQ
67
DILKEVKFLR
77
QLKHPNTIEY
87
KGCYLKEHTA
97
WLVMEYCLGS
107

ASDLLEVHKK
117
PLQEVEIAAI
127
THGALHGLAY
137
LHSHALIHRD
147
IKAGNILLTE
157

PGQVKLADFG
167
SASMASPANS
177
FVGTPYWMAP
187
EVILAMDEGQ
197
YDGKVDIWSL
207

GITCIELAER
217
KPPLFNMNAM
227
SALYHIAQND
237
SPTLQSNEWT
247
DSFRRFVDYC
257

LQKIPQERPT
267
SAELLRHDFV
277
RRDRPLRVLI
287
DLIQRTKDAV
297
RELDNLQYRK
307

MKKILFQ
Residue
Distance (Å)
ILE30
2.807
GLY31
2.579
HIS32
2.949
GLY33
2.574
SER34
3.771
PHE35
2.141
VAL38
2.824
ALA51
2.763
LYS53
2.028
GLU72
4.680
ILE85
2.568
MET101
2.761
GLU102
1.880
Residue
Distance (Å)
TYR103
3.108
CYS104
2.086
LEU105
4.173
GLY106
4.338
SER107
2.825
ASP110
3.292
GLY151
1.941
ASN152
3.089
LEU154
2.492
ALA164
4.362
ASP165
2.524
GLY167
4.625
LYS310
2.771
References  Top
REF 1 Crystal structure of human TAO3 kinase binding ADP

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