Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T63484 | Target Info | |||
| Target Name | Glucose-6-phosphate dehydrogenase (G6PD) | ||||
| Synonyms | Glucose-6-phosphate 1-dehydrogenase | ||||
| Target Type | Successful Target | ||||
| Gene Name | G6PD | ||||
| Biochemical Class | CH-OH donor oxidoreductase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: NADP+ | Ligand Info | |||||
| Structure Description | Crystal structure of Human G6PD Canton | PDB:6JYU | ||||
| Method | X-ray diffraction | Resolution | 1.89 Å | Mutation | Yes | [1] |
| PDB Sequence |
SDTHIFIIMG
38 ASGDLAKKKI48 YPTIWWLFRD58 GLLPENTFIV68 GYARSRLTVA78 DIRKQSEPFF 88 KATPEEKLKL98 EDFFARNSYV108 AGQYDDAASY118 QRLNSHMNAL128 HLGSQANRLF 138 YLALPPTVYE148 AVTKNIHESC158 MSQIGWNRII168 VEKPFGRDLQ178 SSDRLSNHIS 188 SLFREDQIYR198 IDHYLGKEMV208 QNLMVLRFAN218 RIFGPIWNRD228 NIACVILTFK 238 EPFGTEGRGG248 YFDEFGIIRD258 VMQNHLLQML268 CLVAMEKPAS278 TNSDDVRDEK 288 VKVLKCISEV298 QANNVVLGQY308 VGNPDGEGEA318 TKGYLDDPTV328 PRGSTTATFA 338 AVVLYVENER348 WDGVPFILRC358 GKALNERKAE368 VRLQFHDVAG378 DIFHQQCKRN 388 ELVIRVQPNE398 AVYTKMMTKK408 PGMFFNPEES418 ELDLTYGNRY428 KNVKLPDAYE 438 RLILDVFCGS448 QMHFVRSDEL458 LEAWRIFTPL468 LHQIELEKPK478 PIPYIYGSRG 488 PTEADELMKR498 VGFQYEGTYK508 WVNPH
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THR236
4.607
LYS238
2.466
ASN363
4.492
GLU364
3.574
LYS366
2.482
GLU368
4.218
ARG370
2.857
GLU389
4.139
VAL391
4.389
ARG393
2.727
ASN397
3.691
ALA399
3.894
TYR401
2.510
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: beta-D-glucose-6-phosphate | Ligand Info | |||||
| Structure Description | Structure of G6PD-D200N tetramer bound to NADP+ and G6P | PDB:7SNI | ||||
| Method | Electron microscopy | Resolution | 2.50 Å | Mutation | No | [2] |
| PDB Sequence |
QSDTHIFIIM
37 GASGDLAKKK47 IYPTIWWLFR57 DGLLPENTFI67 VGYARSRLTV77 ADIRKQSEPF 87 FKATPEEKLK97 LEDFFARNSY107 VAGQYDDAAS117 YQRLNSHMNA127 LHLGSQANRL 137 FYLALPPTVY147 EAVTKNIHES157 CMSQIGWNRI167 IVEKPFGRDL177 QSSDRLSNHI 187 SSLFREDQIY197 RINHYLGKEM207 VQNLMVLRFA217 NRIFGPIWNR227 DNIACVILTF 237 KEPFGTEGRG247 GYFDEFGIIR257 DVMQNHLLQM267 LCLVAMEKPA277 STNSDDVRDE 287 KVKVLKCISE297 VQANNVVLGQ307 YVGNPDGEGE317 ATKGYLDDPT327 VPRGSTTATF 337 AAVVLYVENE347 RWDGVPFILR357 CGKALNERKA367 EVRLQFHDVA377 GDIFHQQCKR 387 NELVIRVQPN397 EAVYTKMMTK407 KPGMFFNPEE417 SELDLTYGNR427 YKNVKLPDAY 437 ERLILDVFCG447 SQMHFVRSDE457 LREAWRIFTP467 LLHQIELEKP477 KPIPYIYGSR 487 GPTEADELMK497 RVGFQYEGTY507 KWVNPHKL
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Crystal structure of Human G6PD Canton | ||||
| REF 2 | Allosteric role of a structural NADP(+) molecule in glucose-6-phosphate dehydrogenase activity. Proc Natl Acad Sci U S A. 2022 Jul 19;119(29):e2119695119. | ||||
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