Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T62974 Target Info
Target Name Somatostatin receptor type 4 (SSTR4)
Synonyms SSTR4; SS4R
Target Type Clinical trial Target
Gene Name SSTR4
Biochemical Class GPCR rhodopsin
UniProt ID
SSR4_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: (2S)-4-amino-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-2-[(4-methylnaphthalen-1-yl)sulfonylamino]butanamide Ligand Info
Structure Description CryoEM structure of somatostatin receptor 4 (SSTR4) with Gi1 and J-2156 PDB:7XMT
Method Electron microscopy Resolution 2.80 Å Mutation Yes [1]
PDB Sequence
GMVAIQCIYA
55
LVCLVGLVGN
65
ALVIFVILRY
75
AKMKTATNIY
85
LLNLAVADEL
95

FMLSVPFVAS
105
SAALRHWPFG
115
SVLCRAVLSV
125
DGLNMFTSVF
135
CLTVLSVDRY
145

VAVVHPLRAA
155
TYRRPSVAKL
165
INLGVWLASL
175
LVTLPIAIFA
185
DTRPACNLQW
202

PHPAWSAVFV
212
VYTFLLGFLL
222
PVLAIGLCYL
232
LIVGKMRAVA
242
LRAGWQQRRR
252

SEKKITRLVL
262
MFVVVFVLCW
272
MPFYVVQLLN
282
LFLDATVNHV
295
SLILSYANSC
305

ANPILYGFLS
315
DNFRR
Residue
Distance (Å)
PHE96
4.337
SER99
4.025
VAL103
3.568
TRP112
3.544
VAL122
4.436
LEU123
3.553
ASP126
2.628
GLY127
4.185
MET130
3.472
PHE131
3.454
ILE181
3.268
Residue
Distance (Å)
CYS198
3.765
ASN199
3.534
LEU200
3.281
VAL212
3.842
THR215
3.512
PHE275
3.475
TYR276
3.640
GLN279
3.240
LEU297
4.416
TYR301
4.084
References  Top
REF 1 Structural insights into ligand recognition and selectivity of somatostatin receptors. Cell Res. 2022 Aug;32(8):761-772.

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