Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T60366 | Target Info | |||
| Target Name | Ornithine decarboxylase (ODC1) | ||||
| Synonyms | ODC | ||||
| Target Type | Successful Target | ||||
| Gene Name | ODC1 | ||||
| Biochemical Class | Carbon-carbon lyase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Pyridoxal phosphate | Ligand Info | |||||
| Structure Description | Structure of an intellectual disability-associated ornithine decarboxylase variant G84R in complex with PLP | PDB:7U6U | ||||
| Method | X-ray diffraction | Resolution | 1.85 Å | Mutation | Yes | [1] |
| PDB Sequence |
EEFDCHFLDE
16 GFTAKDILDQ26 KINEVSSSDD36 KDAFYVADLG46 DILKKHLRWL56 KALPRVTPFY 66 AVKCNDSKAI76 VKTLAATRTG86 FDCASKTEIQ96 LVQSLGVPPE106 RIIYANPCKQ 116 VSQIKYAANN126 GVQMMTFDSE136 VELMKVARAH146 PKAKLVLRIA156 TDDSKAVCRL 166 SVKFGATLRT176 SRLLLERAKE186 LNIDVVGVSF196 HVGSGCTDPE206 TFVQAISDAR 216 CVFDMGAEVG226 FSMYLLDIGG236 GFPGSEDVKL246 KFEEITGVIN256 PALDKYFPSD 266 SGVRIIAEPG276 RYYVASAFTL286 AVNIIAKKIV296 LEQTFMYYVN319 DGVYGSFNCI 329 LYDHAHVKPL339 LQKRPKPDEK349 YYSSSIWGPT359 CDGLDRIVER369 CDLPEMHVGD 379 WMLFENMGAY389 TVAAASTFNG399 FQRPTIYYVM409 SGPAWQLMQQ419 FQN |
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: APA | Ligand Info | |||||
| Structure Description | A structural insight into the inhibition of human and Leishmania donovani ornithine decarboxylases by 3-aminooxy-1-aminopropane | PDB:2OO0 | ||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [2] |
| PDB Sequence |
AGENLYFQSL
0 MNNFGNEEFD10 CHFLDEGFTA20 KDILDQKINE30 VSSSDDKDAF40 YVADLGDILK 50 KHLRWLKALP60 RVTPFYAVKC70 NDSKAIVKTL80 AATGTGFDCA90 SKTEIQLVQS 100 LGVPPERIIY110 ANPCKQVSQI120 KYAANNGVQM130 MTFDSEVELM140 KVARAHPKAK 150 LVLRIATDDS160 KAVCRLSVKF170 GATLRTSRLL180 LERAKELNID190 VVGVSFHVGS 200 GCTDPETFVQ210 AISDARCVFD220 MGAEVGFSMY230 LLDIGGGFPG240 SEDVKLKFEE 250 ITGVINPALD260 KYFPSDSGVR270 IIAEPGRYYV280 ASAFTLAVNI290 IAKKIVLEQT 313 FMYYVNDGVY323 GSFNCILYDH333 AHVKPLLQKR343 PKPDEKYYSS353 SIWGPTCDGL 363 DRIVERCDLP373 EMHVGDWMLF383 ENMGAYTVAA393 ASTFNGFQRP403 TIYYVMSGPA 413 WQLMQQFQN
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Pentane-1,5-diamine | Ligand Info | |||||
| Structure Description | A structural insight into the inhibition of human and Leishmania donovani ornithine decarboxylases by 3-aminooxy-1-aminopropane | PDB:2OO0 | ||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [2] |
| PDB Sequence |
AGENLYFQSL
0 MNNFGNEEFD10 CHFLDEGFTA20 KDILDQKINE30 VSSSDDKDAF40 YVADLGDILK 50 KHLRWLKALP60 RVTPFYAVKC70 NDSKAIVKTL80 AATGTGFDCA90 SKTEIQLVQS 100 LGVPPERIIY110 ANPCKQVSQI120 KYAANNGVQM130 MTFDSEVELM140 KVARAHPKAK 150 LVLRIATDDS160 KAVCRLSVKF170 GATLRTSRLL180 LERAKELNID190 VVGVSFHVGS 200 GCTDPETFVQ210 AISDARCVFD220 MGAEVGFSMY230 LLDIGGGFPG240 SEDVKLKFEE 250 ITGVINPALD260 KYFPSDSGVR270 IIAEPGRYYV280 ASAFTLAVNI290 IAKKIVLEQT 313 FMYYVNDGVY323 GSFNCILYDH333 AHVKPLLQKR343 PKPDEKYYSS353 SIWGPTCDGL 363 DRIVERCDLP373 EMHVGDWMLF383 ENMGAYTVAA393 ASTFNGFQRP403 TIYYVMSGPA 413 WQLMQQFQN
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .N2P or .N2P2 or .N2P3 or :3N2P;style chemicals stick;color identity;select .A:201 or .A:202 or .A:238 or .A:239 or .A:240 or .A:241 or .A:243 or .A:244 or .A:277 or .A:281 or .A:385; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure and Enzymatic Activity of an Intellectual Disability-Associated Ornithine Decarboxylase Variant, G84R. ACS Omega. 2022 Sep 13;7(38):34665-34675. | ||||
| REF 2 | A structural insight into the inhibition of human and Leishmania donovani ornithine decarboxylases by 1-amino-oxy-3-aminopropane. Biochem J. 2007 Jul 15;405(2):261-8. | ||||
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