Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T60213 | Target Info | |||
| Target Name | Bone morphogenetic protein receptor (BMPR2) | ||||
| Synonyms | PPH1; Bone morphogenetic protein receptor type-2; Bone morphogenetic protein receptor type II; BMPR-II; BMPR-2; BMP type-2 receptor; BMP type II receptor | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | BMPR2 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: adenosine diphosphate | Ligand Info | |||||
| Structure Description | Crystal structure of the kinase domain of BMPR2-D485G | PDB:6UNP | ||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | Yes | [1] |
| PDB Sequence |
DLDNLKLLEL
208 IGRGRYGAVY218 KGSLDERPVA228 VKVFSFANRQ238 NFINEKNIYR248 VPLMEHDNIA 258 RFIVGDERVT268 ADGRMEYLLV278 MEYYPNGSLK289 YLSLHTSDWV299 SSCRLAHSVT 309 RGLAYLHTEL319 PRGDHYKPAI329 SHRDLNSRNV339 LVKNDGTCVI349 SDFGLSMRLT 359 GNRLVRPEVG378 TIRYMAPEVL388 EGAVNLRDES399 ALKQVDMYAL409 GLIYWEIFMR 419 CTDLFPGESV429 PEYQMAFQTE439 VGNHPTFEDM449 QVLVSREKQR459 PKFPEAWKEN 469 SLAVRSLKET479 IEDCWGQDAE489 ARLTAQAEER500 MAELMMIWE
|
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ILE209
3.628
GLY210
3.517
ARG211
3.868
GLY212
3.108
ARG213
3.233
TYR214
2.787
GLY215
2.799
VAL217
3.520
ALA228
3.423
LYS230
2.729
GLU243
4.712
MET279
3.314
GLU280
2.821
|
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: S-(Dimethylarsenic)Cysteine | Ligand Info | |||||
| Structure Description | Crystal structure of the kinase domain of BMPR2-D485G | PDB:6UNP | ||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | Yes | [1] |
| PDB Sequence |
DLDNLKLLEL
208 IGRGRYGAVY218 KGSLDERPVA228 VKVFSFANRQ238 NFINEKNIYR248 VPLMEHDNIA 258 RFIVGDERVT268 ADGRMEYLLV278 MEYYPNGSLK289 YLSLHTSDWV299 SSCRLAHSVT 309 RGLAYLHTEL319 PRGDHYKPAI329 SHRDLNSRNV339 LVKNDGTCVI349 SDFGLSMRLT 359 GNRLVRPEVG378 TIRYMAPEVL388 EGAVNLRDES399 ALKQVDMYAL409 GLIYWEIFMR 419 CTDLFPGESV429 PEYQMAFQTE439 VGNHPTFEDM449 QVLVSREKQR459 PKFPEAWKEN 469 SLAVRSLKET479 IEDCWGQDAE489 ARLTAQAEER500 MAELMMIWE
|
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SER286
3.148
LEU287
1.335
LYS289
1.320
TYR290
3.274
LEU291
3.393
SER292
2.992
SER336
2.895
ARG337
3.739
VAL339
4.998
MET356
4.763
ARG357
4.523
LEU358
4.053
VAL364
4.327
PRO366
4.348
ASN393
4.074
LEU394
3.339
ARG395
3.368
|
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural basis for ALK2/BMPR2 receptor complex signaling through kinase domain oligomerization. Nat Commun. 2021 Aug 16;12(1):4950. | ||||
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