Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T59631 Target Info
Target Name Programmed cell death protein 1 (PD-1)
Synonyms hPD1; hPD-1; Protein PD1; Protein PD-1; PD1; CD279
Target Type Successful Target
Gene Name PDCD1
Biochemical Class Immunoglobulin
UniProt ID
PDCD1_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: (2S,3R)-2-azaniumyl-3-hydroxybutanoate Ligand Info
Structure Description Complex structure of PD1 and 609A-Fab PDB:7VUX
Method X-ray diffraction Resolution 1.64 Å Mutation No [1]
PDB Sequence
MWNPPTFSPA
40
LLVVTEGDNA
50
TFTCSFSNTS
60
ESFVLNWYRM
70
SPSNQTDKLA
80

AFPEDRSQPG
90
QDSRFRVTQL
100
PNGRDFHMSV
110
VRARRNDSGT
120
YLCGAISLAP
130

KAQIKESLRA
140
ELRVTERRAE
150
VP
Residue
Distance (Å)
VAL151
3.837
Residue
Distance (Å)
PRO152
1.609
References  Top
REF 1 A strategy for the efficient construction of anti-PD1-based bispecific antibodies with desired IgG-like properties. MAbs. 2022 Jan-Dec;14(1):2044435.

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