Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T58924 | Target Info | |||
| Target Name | SRSF protein kinase 2 (SRPK2) | ||||
| Synonyms | Serine/arginine-rich protein-specific kinase 2; SR-protein-specific kinase 2; SFRS protein kinase 2 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | SRPK2 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: L-751250 | Ligand Info | |||||
| Structure Description | Structure of human serine-arginine-rich protein-specific kinase 2 (SRPK2) bound to purvalanol B | PDB:2X7G | ||||
| Method | X-ray diffraction | Resolution | 2.50 Å | Mutation | No | [1] |
| PDB Sequence |
PVKIGDLFNG
90 RYHVIRKLGW100 GHFSTVWLCW110 DMQGKRFVAM120 KVVKSAQHYT130 ETALDEIKLL 140 KCVRESDPSD150 PNKDMVVQLI160 DDFKISGMNG170 IHVCMVFEVL180 GHHLLKWIIK 190 SNYQGLPVRC200 VKSIIRQVLQ210 GLDYLHSKCK220 IIHTDIKPEN230 ILMCVDDAYV 240 RRMAAELLVN525 PLDPRNADKI535 RVKIADLGNA545 CWVHKHFTED555 IQTRQYRSIE 565 VLIGAGYSTP575 ADIWSTACMA585 FELATGDYLF595 EPHSGEDYSR605 DEDHIAHIIE 615 LLGSIPRHFA625 LSGKYSREFF635 NRRGELRHIT645 KLKPWSLFDV655 LVEKYGWPHE 665 DAAQFTDFLI675 PMLEMVPEKR685 ASAGECLRHP695 WLNS
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| Ligand Name: 5-Methyl-~{n}-[2-(4-Methylpiperazin-1-Yl)-5-(Trifluoromethyl)phenyl]furan-2-Carboxamide | Ligand Info | |||||
| Structure Description | Crystal structure of SRPK2 in complex with compound 1 | PDB:5MYV | ||||
| Method | X-ray diffraction | Resolution | 2.90 Å | Mutation | No | [2] |
| PDB Sequence |
YHPVKIGDLF
88 NGRYHVIRKL98 GWGHFSTVWL108 CWDMQGKRFV118 AMKVVKSAQH128 YTETALDEIK 138 LLKCVRESDP148 SDPNKDMVVQ158 LIDDFKISGM168 NGIHVCMVFE178 VLGHHLLKWI 188 IKSNYQGLPV198 RCVKSIIRQV208 LQGLDYLHSK218 CKIIHTDIKP228 ENILMCVDDA 238 YVRRMAAEAT248 EWQKLLVNPL527 DPRNADKIRV537 KIADLGNACW547 VHKHFTEDIQ 557 TRQYRSIEVL567 IGAGYSTPAD577 IWSTACMAFE587 LATGDYLFEP597 HSGEDYSRDE 607 DHIAHIIELL617 GSIPRHFALS627 GKYSREFFNR637 RGELRHITKL647 KPWSLFDVLV 657 EKYGWPHEDA667 AQFTDFLIPM677 LEMVPEKRAS687 AGECLRHPWL697 NS |
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure of Human Serine-Arginine-Rich Protein- Specific Kinase 2 (Srpk2) Bound to Purvalanol B | ||||
| REF 2 | Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease. ACS Chem Biol. 2017 Mar 17;12(3):825-832. | ||||
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