Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T58361 Target Info
Target Name Transforming protein RhoB (RHOB)
Synonyms RhoB
Target Type Literature-reported Target
Gene Name RHOB
UniProt ID
RHOB_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Guanosine-5'-Diphosphate Ligand Info
Structure Description The crystal structure of RhoB in the GDP-bound state PDB:2FV8
Method X-ray diffraction Resolution 1.90 Å Mutation No [1]
PDB Sequence
YFQSMIRKKL
8
VVVGDGACGK
18
TCLLIVFSKD
28
EFPFENYVAD
45
IEVDGKQVEL
55

ALWDTAGQED
65
YDRLRPLSYP
75
DTDVILMCFS
85
VDSPDSLENI
95
PEKWVPEVKH
105

FCPNVPIILV
115
ANKKDLRSDE
125
HVRTELARMK
135
QEPVRTDDGR
145
AMAVRIQAYD
155

YLECSAKTKE
165
GVREVFETAT
175
RAALQKRYGS
185
Residue
Distance (Å)
ASP13
3.699
GLY14
3.766
ALA15
2.743
CYS16
3.289
GLY17
3.068
LYS18
2.775
THR19
2.605
CYS20
2.748
LEU21
4.795
PHE30
3.677
Residue
Distance (Å)
ASP59
4.785
ALA61
3.632
GLU64
4.138
LYS118
2.935
LYS119
4.869
ASP120
2.946
LEU121
3.444
SER160
3.548
ALA161
3.010
LYS162
3.228
Ligand Name: Guanosine-5'-Triphosphate Ligand Info
Structure Description Crystal structure of Human RHOB Q63L in complex with GTP PDB:6HXU
Method X-ray diffraction Resolution 1.19 Å Mutation Yes [2]
PDB Sequence
AAIRKKLVVV
11
GDGACGKTCL
21
LIVFSKDEFP
31
EVYVPTVFEN
41
YVADIEVDGK
51

QVELALWDTA
61
GLEDYDRLRP
71
LSYPDTDVIL
81
MCFSVDSPDS
91
LENIPEKWVP
101

EVKHFCPNVP
111
IILVANKKDL
121
RSDEHVRTEL
131
ARMKQEPVRT
141
DDGRAMAVRI
151

QAYDYLECSA
161
KTKEGVREVF
171
ETATRAALQK
181
RY
Residue
Distance (Å)
GLY12
4.690
ASP13
3.816
GLY14
2.561
ALA15
2.210
CYS16
2.865
GLY17
2.334
LYS18
1.817
THR19
2.122
CYS20
1.989
LEU21
4.228
PHE30
2.363
PRO31
3.828
GLU32
4.905
TYR34
1.877
VAL35
4.402
PRO36
2.716
Residue
Distance (Å)
THR37
1.975
ASP59
4.911
THR60
4.159
ALA61
3.742
GLY62
2.108
LEU63
3.381
ASN117
4.712
LYS118
2.479
LYS119
4.788
ASP120
1.968
LEU121
2.559
SER160
2.871
ALA161
2.513
LYS162
2.325
THR163
4.733
Click to View More Binding Site Information of This Target and Ligand Pair
References  Top
REF 1 The crystal structure of RhoB in the GDP-bound state
REF 2 A Targeted Protein Degradation Cell-Based Screening for Nanobodies Selective toward the Cellular RHOB GTP-Bound Conformation. Cell Chem Biol. 2019 Nov 21;26(11):1544-1558.e6.

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