Binding Site Information of Target

Content Navigation (  All   None )                                      
Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T57050 Target Info
Target Name Zinc finger-containing ubiquitin peptidase 1 (ZUP1)
Synonyms Zinc finger with UFM1-specific peptidase domain protein; ZUFSP; Lys-63-specific deubiquitinase ZUFSP; DUB; C6orf113
Target Type Patented-recorded Target
Gene Name ZUP1
Biochemical Class Peptidase
UniProt ID
ZUP1_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Allylamine Ligand Info
Structure Description Crystal structure of the covalent complex between deubiquitinase ZUFSP (ZUP1) and Ubiquitin-PA PDB:6EI1
Method X-ray diffraction Resolution 1.73 Å Mutation No [1]
PDB Sequence
LQQEEDRKRR
249
SEESRQEIEE
259
FQKLQRQYGL
269
DNSGGYKQQQ
279
LRNMEIEVNR
289

GRMPPSEFHR
299
RKADMMESLA
309
LGFDDGKTKT
319
SGIIEALHRY
329
YQNAATDVRR
339

VWLSSVVDHF
349
HSSLGDKGWG
359
CGYRNFQMLL
369
SSLLQNDAYN
379
DCLKGMLIPC
389

IPKIQSMIED
399
AWKEGFDPQG
409
ASQLNNRLQG
419
TKAWIGACEV
429
YILLTSLRVK
439

CHIVDFHKST
449
GPLGTHPRLF
459
EWILNYYSSS
473
PKVVCTSKPP
483
IYLQHQGHSR
493

TVIGIEEKKN
503
RTLCLLILDP
513
GCPSREMQKL
523
LKQDIEASSL
533
KQLRKSMGNL
543

KHKQYQILAV
553
EGALSLEEKL
563
ARRQASQVFT
573
AEKIP
Residue
Distance (Å)
GLY357
2.880
TRP358
2.429
GLY359
3.762
CYS360
1.663
GLY361
3.904
TRP423
2.840
Residue
Distance (Å)
ILE424
4.567
GLN487
4.764
GLY490
2.307
HIS491
2.883
SER492
4.292
PRO513
4.347
References  Top
REF 1 A family of unconventional deubiquitinases with modular chain specificity determinants. Nat Commun. 2018 Feb 23;9(1):799.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.