Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T56308 Target Info
Target Name Interleukin-11 (IL11)
Synonyms Oprelvekin; IL-11; Adipogenesis inhibitory factor; AGIF
Target Type Clinical trial Target
Gene Name IL11
Biochemical Class Cytokine: interleukin
UniProt ID
IL11_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Formamide Ligand Info
Structure Description The crystal structure of human interleukin-11 PDB:4MHL
Method X-ray diffraction Resolution 2.09 Å Mutation No [1]
PDB Sequence
DPRAELDSTV
43
LLTRSLLADT
53
RQLAAQLRDK
63
FPADGDHNLD
73
SLPTLAMSAL
85

GALQLPGVLT
95
RLRADLLSYL
105
RHVQWLRRAG
115
GSSLKTLEPE
125
LGTLQARLDR
135

LLRRLQLLMS
145
RLALPQDPPA
158
PPLAPPSSAW
168
GGIRAAHAIL
178
GGLHLTLDWA
188

VRGLLLLKTR
198
L
Residue
Distance (Å)
ARG54
3.358
ALA58
2.799
GLN59
4.709
ARG61
2.651
ASP62
3.927
PHE64
4.111
PRO65
2.944
ALA66
3.527
ASP67
3.100
GLY68
4.980
HIS70
2.844
Residue
Distance (Å)
ARG112
4.209
GLY127
3.216
THR128
3.789
ALA131
3.735
ARG132
3.056
ARG135
4.851
TRP168
3.396
ILE171
3.548
ARG172
3.442
HIS175
3.562
HIS182
2.953
References  Top
REF 1 The structure of human interleukin-11 reveals receptor-binding site features and structural differences from interleukin-6. Acta Crystallogr D Biol Crystallogr. 2014 Sep;70(Pt 9):2277-85.

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