Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T55916 | Target Info | |||
| Target Name | Voltage-gated potassium channel Kv7.4 (KCNQ4) | ||||
| Synonyms | Voltage-gated potassium channel subunit Kv7.4; Potassium channel alpha subunit KvLQT4; KQT-like 4; KCNQ4 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | KCNQ4 | ||||
| Biochemical Class | Voltage-gated ion channel | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: (1S,2S,4R)-N-(2,4,6-trimethylphenyl)bicyclo[2.2.1]heptane-2-carboxamid | Ligand Info | |||||
| Structure Description | Structure of human KCNQ4-ML213 complex with PIP2 | PDB:7VNP | ||||
| Method | Electron microscopy | Resolution | 2.79 Å | Mutation | No | [1] |
| PDB Sequence |
SAAHKRYRRL
83 QNWVYNVLER93 PRGWAFVYHV103 FIFLLVFSCL113 VLSVLSTIQE123 HQELANECLL 133 ILEFVMIVVF143 GLEYIVRVWS153 AGCCCRYRGW163 QGRFRFARKP173 FCVIDFIVFV 183 ASVAVIAATS201 ALRSMRFLQI211 LRMVRMDRRG221 GTWKLLGSVV231 YAHSKELITA 241 WYIGFLVLIF251 ASFLVYLAEK261 DANSDFSSYA271 DSLWWGTITL281 TTIGYGDKTP 291 HTWLGRVLAA301 GFALLGISFF311 ALPAGILGSG321 FALKVQEQHR331 QKHFEKRRMP 341 AANLIQAAWR351 LYSTDPAVKT532 VIRSIRILKF542 LVAKRKFKET552 LRPYDVKDVI 562 EQYSAGHLDM572 LGRIKSLQTR582 VD
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate | Ligand Info | |||||
| Structure Description | Structure of human KCNQ4-ML213 complex with PIP2 | PDB:7VNP | ||||
| Method | Electron microscopy | Resolution | 2.79 Å | Mutation | No | [1] |
| PDB Sequence |
SAAHKRYRRL
83 QNWVYNVLER93 PRGWAFVYHV103 FIFLLVFSCL113 VLSVLSTIQE123 HQELANECLL 133 ILEFVMIVVF143 GLEYIVRVWS153 AGCCCRYRGW163 QGRFRFARKP173 FCVIDFIVFV 183 ASVAVIAATS201 ALRSMRFLQI211 LRMVRMDRRG221 GTWKLLGSVV231 YAHSKELITA 241 WYIGFLVLIF251 ASFLVYLAEK261 DANSDFSSYA271 DSLWWGTITL281 TTIGYGDKTP 291 HTWLGRVLAA301 GFALLGISFF311 ALPAGILGSG321 FALKVQEQHR331 QKHFEKRRMP 341 AANLIQAAWR351 LYSTDPAVKT532 VIRSIRILKF542 LVAKRKFKET552 LRPYDVKDVI 562 EQYSAGHLDM572 LGRIKSLQTR582 VD
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ARG93
3.241
ARG95
2.771
PHE99
3.315
PHE106
2.826
ARG159
3.500
LYS172
2.936
PRO173
4.614
PHE174
4.457
ILE177
3.569
LEU212
3.183
VAL215
3.636
ARG216
4.759
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural insights into the lipid and ligand regulation of a human neuronal KCNQ channel. Neuron. 2022 Jan 19;110(2):237-247.e4. | ||||
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